Thread by @hildabast

Catch-up 🧵 on reports of Covid vax & immunocompromised people. Overall, starting to look like a head-to-head trial of Moderna & BNT-Pfizer vax for some groups would be worthwhile ... #IC

...78 people on hemodialysis in Spain getting Moderna vax: immune response grew slowly, but was high 6 weeks after being fully vaxed... academic.oup.com/ndt/advance-ar… #IC

...32 people on peritoneal dialysis in Spain after Moderna vax: only 1 didn’t seroconvert kidney-international.org/article/S0085-… ... #IC

...Small numbers, but still a bit encouraging: Experience from the US. Of 7 people with kidney transplants who were fully vaxed with mRNA & later diagnosed with Covid-19, while 4 were hospitalized, none needed intensive treatment onlinelibrary.wiley.com/doi/pdfdirect/… ...#IC

...2 more studies showing lower response in people with solid organ transplants:
- 16 people after BNT-Pfizer vax (Italy) onlinelibrary.wiley.com/doi/epdf/10.11…
- Rate of Covid-19 in 164 people with kidney transplants after BNT-Pfizer vax (Croatia) onlinelibrary.wiley.com/doi/10.1111/17…
...#IC

...Study from the US: people with solid organ transplants who had the J&J vax - only 12 people. Immune response was far lower for those 12 compared to 725 people with transplants who had mRNA Covid vaxes journals.lww.com/transplantjour… ...#IC

...BNT-Pfizer vax in kidney patients, from France found low response after transplants (n=225), better in hemodialysis (n=45) jasn.asnjournals.org/content/early/… ...#IC

...85 on hemodialysis & 24 on peritoneal dialysis in France after BNT-Pfizer vax: mostly good response, but 2nd dose needed & authors suggest some may need a third
academic.oup.com/ndt/advance-ar… ...#IC

...2 more studies in people with cancer.

16 people chronic myeloid leukemia (CML) in the UK after a single dose of BNT-Pfizer vax: responses in most people – authors suggest may have better responses than people with some other cancers onlinelibrary.wiley.com/doi/epdf/10.11… ...#IC

...167 people with chronic lymphocytic leukemia (CLL) after BNT-Pfizer vax, Israel. Response was “markedly impaired and affected by disease activity and treatment”
ashpublications.org/blood/article/… ...#IC

...26 people with inborn errors of immunity, Israel, BNT-Pfizer vax. Most were on immunoglobulin replacement therapy & most (but not all) developed immune responses to the vaccine jacionline.org/article/S0091-… ...#IC

...82 healthcare workers with immune diseases in Turkey after Sinovac’s CoronaVac: most developed strong responses, but those on immunosuppressive drugs had lower responses: authors suggest 3rd dose should be studied link.springer.com/article/10.100… #IC

...And another in people with lymphoma, this time 129 in the UK, either BNT-Pfizer or AZ vax. Differences again for people in treatment (& for indolent incurable malignancy) medrxiv.org/content/10.110… (Preprint) #IC