Thread by @Rumindahg

#Delta vs #Sinopharm
This will be based on assumption

Summary
Vaccines won't make you immortal

It's individual discipline, vaccination & our governments policies which will ride us out of this wave.

1/
#COVID19SL
#VaccinatedSL

The bad news

First, AFAIK there is no data of Sinopharm vs Delta.

We also have real world evidence of break through infections occurring in 🇸🇨🇲🇳🇧🇭

But both of these points can be viewed from a different angle

2/

Delta's qualities

Deltas massive impact on the world is mainly due to its transmissibility. 97% more.

It also has immune evasion (More severe disease & vaccine ineffectiveness) BUT NO WIDESPREAD ESCAPE FROM VACCINES

But its not as evasive as #Beta (B.1
351)
4/

Delta, Beta & Sinopharm

"Good news" is that there is data showing Sinopharm has the ability to produce antibodies against #Beta. (Though its much less)
=NO VACCINE EVASION

So we can assume that Sinopharm will develop a better response against #Delta
5/
nejm.org/doi/full/10.10…

Preventing severe infection

It's not all about antibodies, T cell immunity matters as well.

If antibodies prevents the initial infection, T cells have more of a role in preventing severe disease & immune memory.

So does #Sinopharm induce a good T cell response?
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Sinopharm & T cells

Unfortunately again we don't have data on this,
But in theory Inactivated vaccines such as Sinopharm should give a robust T-cell reaction as the whole virus is presented

This is shown in other Inactivated vaccines such as Covaxin, Sinovac & Valneva
7/

Sinopharm, Covaxin & Delta

@BharatBiotech Covaxin which is also an inactivated vaccine showed a good immune response vs Delta

So we can assume that Sinopharm too will give an adequate antibody against Delta
8/
biorxiv.org/content/10.110…

What happened in Seychelles, Bahrain and Mongolia?

They had high vaccination rates with Sinopharm but still had a spike in cases

But in all 3 countries Govt statememts showed that most of the severe cases were of unvaccinated

There were also concerns of opening up too early
9/

Assumption Sinopharm vs Delta

So we can assume that Sinopharm will have a drop in efficacy against the Delta variant but should be able to restrict severe disease to a point that it is manageable by the system.

But please understand that vaccines are just one tool we have
10/

It's not all about vaccines

Vaccines won't make you immortal, there is never a 100% here.

Think of it like this, just because you get a stent for a heart attack, that shouldnt stop you from taking medication, exercising, controlling diet & stopping smoking.

11/

Summary

There is good reason to believe that Sinopharm will work against Delta

But efficacy will be ⬇️ so don't be surprised if there are breakthrough cases

Main point is to reduce severe cases

Cant depend only on vaccines. Need to ⬆️ testing, masks, distancing & ventilation