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29 Jun, 5 tweets, 3 min read
Ready to have your mind blown 🤯!?

1/ What would you predict would happen to fasting triglycerides and LDL if you just ate a TON of fat and Saturated Fat. Like, if you drank 6000 kCal and 1.6 Liters of heavy cream?!

Trigs (fat in blood) and LDL-C would obviously go up right?
2/ Well, if your #keto #lchf not necessarily. In fact, overeating tons of fat can DROP your fasting triglycerides and LDL like a stone! WTF?! So what’s going on…
3/ Well, chylomicrons from the intestines (and VLDL secreted by the liver) carry triglycerides. But their residence time in the blood is very short, such that when you have a fasted lipid test, the fat you ate should have been deposited in storage around your body. BUT…
4/ being overfed, even if low carb, will increase basal insulin, sending a signal to fat cells to grow. Thus, the fat cells suck up triglycerides from the blood even more in an effort to expand. AND this expansion may be facilitated by membrane components provided by LDL. Thus…
5/ eating tons of sat fat while low carb Will drop your LDL-C and LDL-P and Trigs on a faster test. So brilliant! So mechanistic AND - weirdly - so intuitive when you think about it
.@siobhan_huggins .@DaveKeto .@Ad_SotoMota .@DoctorTro
cholesterolcode.com/tandem-experim…

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More from @nicknorwitz

Nick Norwitz Profile picture
29 Jun
I usually don’t get “into it” with people but recently did with a nutritionist who I felt mismanaged me in college. I threw out 5 on the spot questions..

1/ How many g of sugar are in a full mango 🥭?
Guess = 12. Answer = ~46.

2/ Grams fiber in an avo🥑?
Guess =3. Answer = ~13.
3/ Protein in 1 Oz pecans?
Guess = 9 g. Answer = ~2.5G

4/ potassium in a banana 🍌 (I mentioned 3.5-4.7 g/day is desirable)
Guess = 2 g. Answer ~0.4 g

5/ what proportion of red meat 🥩fat is SAT fat?
Guess = 75%.

Answer = ??? (U Guess! do u know more than this nutritionist?)
I’m usually a pretty accepting and level headed person, but this was a person who presented herself as a nutrition authority at a time when I was suffering and needed help. This, I suffered…
Read 4 tweets
Nick Norwitz Profile picture
23 Jun
1/ If you can’t convince them to join your nutrition religion...

bioengineer the next generation to conform 🧬

Or release a plague of ticks 🕷

Sounds like an ethical and democratic idea 💡
2/ I feel strange about this one because I’m actually really liberal when it comes to genetic engineering. You want to crispr by brain for Apoe2, great. I’m your lab rat... but this is really appalling. I’m not even anti-plant base, but the fact that he would propose this...
3/ demonstrates an extreme example of tunnel vision and clear close-mindedness about the issue of eating sustainably for the planet and for human health. It’s like the low-fat saga but with 21st century genetic engineering tools 🛠...
Read 5 tweets
Nick Norwitz Profile picture
22 May
Get ready for a thread of questions about the recent ApoB shortens lifespan Mendelian randomization study, posed as my top 8 questions.

Thanks everyone in advance for their thoughts, genuinely. .@DaveKeto .@ethanjweiss .@DrNadolsky

sciencedirect.com/science/articl…
1/ How robust were the instruments? Were derived from linkage disequilibrium clumping w clumping parameters of 1 million nts, including 229 SNPs 4ApoB. Stated that tool would “not be considered weak,” Can someone explain this to the Twitter lay audience please?
2/ Building on that, while they adjusted for genetic parameters, I didn’t see anything about adjusting for medications? If they’re talking biomarker data and not adjusting for meds doesn’t the analysis appear vulnerable to healthy use bias?
Read 9 tweets
Nick Norwitz Profile picture
27 Apr
Public Apology Thread
1/ A couple days ago I posted a tweet that I intended to be a commentary on the state of diabetes management in the US. What I didn’t realize at the time is that the image had a lot of historical baggage and suggested a patient-blaming perspective...
2/ Maybe I should have been aware of this history or maybe it’s irrelevant. I’m not asking for forgiveness for that ignorance. The point is that it seriously offended some people. In the hours during which the Tweet is up, before I gathered how it was really hurting people...
3/ and took it down, I doubled down on it in responses. The blunt truth was that I was resistant to listening because I got caught in the heat of aggressive comments, including a few violent threats. Excuses aside, I’m sorry to anyone I hurt. The LAST thing...
Read 5 tweets
Nick Norwitz Profile picture
5 Apr
Prepare for a thread about Well-formulated #Keto Adherence Paper that just came out.

Randomized crossover trial of 2x12-week #keto #LCHF vs. #Mediterranean diet.

Results show equally sustainable given the right conditions, but...
Researchers designed study that during first 4 weeks of each diet, food was provided & during the next 8 they had to buy their own. Baseline&followup adherence scores were also collected. All this allowed researchers to determine how sustainable diets were under diff conditions
baseline #keto adherence score was lower than Medi score. BUT during the time period when food was provided AND when they had to buy their own food, mean keto score was equal to or higher than Medi score. At the follow-up #keto score had dropped again. From this I conclude...
Read 6 tweets
Nick Norwitz Profile picture
26 Feb
nature.com/articles/s4159…
Some thoughts on why these results don't mean much to me
1/ It was 2 weeks, which is short term and not enough time for adaptation (see point 8 and others on this)

2/ "Both diets were low in ultra-processed food" is a misrepresentation....
...the low-carb diet was, IMO, unfairly weighted by processed foods and oils including mayo that I assume was made with soybean oil (correct me if I'm wrong), processed cheeses like "American cheese", and so on. It was also weighted towards meats and A1 dairy
3/LC diet appears far more palatable, and both diets were designed by the investigators, not freely chosen by the participants. If my snack options were unlimited roasted salted nuts sitting in front of me or dry edamame, apricots, and raisins, I'd eat more kCal of nuts too.
Read 8 tweets

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