Thread by @nicknorwitz

New paper tries to claim high inter-individual variability as an excuse for backing the notion that #saturated fat is unhealthy. Things that I thought as I read…

1/ Abstract depicts sat fat as a burger with fries. Sigh...

atherosclerosis-journal.com/article/S0021-…

2/ calls out isocaloric replacement studies 4replacing SAT w carbs rather than PUFA. Fair point, but what practical options r available to people in this world. How r ppl going to read this article? Trade butter for raw tahini, or soybean oil margarine, or go for low-fat cookie?

3/ Cite whole foods complex matrix as a confounding variable. Maybe just say eat whole food and not processed junk? most of American’s sat fat comes from sweets and pasteries, not whole foods. let's just agree the ice cream isn't saving your heart health, don't lump in the steak

4/ “48% of this variation could be accounted for by baseline LDL-C” …. HAHA!!! Oh stay tuned on this one…
.@DaveKeto .@Ad_SotoMota .@DoctorTro

5/ Interesting how persons between 30 and 70 who appear physically well and have a good appetite passes as the definition for “metabolically healthy” (fig 2, ref 42). Is that how you define metaboically healthy?

6/ “As such, a serum biomarker of serum LDL-C responsiveness to the replacement of dietary SFA would have major utility in increasing the power to discriminate disease risk” I agree BUT have prediction. Bet low body fat would be a great predictor for high LDL bump with sat fat