"I'm #pregnant and I want to get the #COVID19 #vaccine to protect myself and my baby. But should I wait until after 12 weeks?"

🧵...
Two studies have looked at pregnancy-specific adverse events following COVID-19 vaccination in the first trimester of pregnancy.

Both found no increased risk of miscarriage.... 2/

nejm.org/doi/full/10.10…

jamanetwork.com/journals/jama/…
The other thing that is a theoretical worry in the first trimester is a high fever (more than 39C for more than 24h) affecting the baby's development.

Although mild fevers are a common side-effect of vaccination, a fever as severe as this is really uncommon... 3/
... in fact, you are more likely to experience such a fever if you catch COVID 🦠. 4/
Furthermore, if you do get a post-vax fever, bringing it down with paracetamol will prevent any such problems.

Paracetamol is safe in pregnancy and does not stop the vaccine working. 5/

Here's the guidance from @RCObsGyn on this. For those in the USA, the guidance from @acog is the same. 6/

rcog.org.uk/en/guidelines-… Image
So the evidence says that if you want to just get protected, there's no reason not to get your #COVID19 #vaccine in the first 12 weeks of #pregnancy.

(But take paracetamol if you get a fever). 7/
But some people just feel more comfortable waiting until after 12 weeks. Is that okay? 8/
COVID is most dangerous after 28 weeks of pregnancy, when it is associated with an increased risk of intensive care for you and your baby, and an increased risk your baby will be preterm or stillborn. 9/

bmj.com/content/370/bm…
If you delay your first dose to 12 weeks, under the current interdose interval in the UK, you should be fully protected by shortly after 20 weeks.

That's still well in advance of 28 weeks. 10/
So I would say that, if you feel more comfortable waiting until 12 weeks, the evidence suggests that this should not be harmful.

But remember, you don't have to wait until 12 weeks if you'd rather just get on with it! 11/11

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More from @VikiLovesFACS

19 Jul
After I wrote this thread about the potential effects of COVID vaccination in pregnancy and the lack of such effects in other vaccines, perinatal epidemilogist @deshaynef got in touch to tell me about some work she has done in this area... 🧵
Her group has published two papers doing 3-5 year follow-up on the babies of people vaccinated against flu in pregnancy.

👉 Flu vaccination in pregnancy was not associated with adverse outcomes in children later on. 2/
Read 5 tweets
16 Jul
A question I get asked *a lot* is…

“What are the long-term effects on babies born after #COVID19 #vaccination in #pregnancy?”

So let’s talk about what we know… 🧵
Let’s start by looking at the effects at birth. We now have four large datasets from three countries telling us that babies born after vaccination in pregnancy are normal. 2/

USA

nejm.org/doi/full/10.10…

medrxiv.org/content/10.110…
Read 12 tweets
15 Jul
Lots of ppl are asking about this article in the Daily Mail. The headline implies we have no idea if the Moderna #COVID19 #vaccine is safe in #pregnancy, despite 1000's having had it.

We actually know that it's safe *because* 1000's have had it... 🧵

dailymail.co.uk/health/article…
Pregnant people were not included in the first rounds of the clinical trials. However, following good safety and efficacy results in the first rounds, both Pfizer and Janssen quickly extended their trials into this group. 2/
Pfizer's trial in pregnant people started in February, and Janssen's in March, both without much fanfare. This is simply Moderna following suit. 3/
Read 16 tweets
14 Jul
Periodically, I get a lot of heat for using gender neutral phrases like “pregnant people” or “people who have periods” rather than “women”.

So today, I’d like to take a few moments to explain why I do that, including some of my more personal reasons… 🧵
But let’s start by being clear that women are people!

So these phrases include pregnant women and women who have periods. 2/
Second, I am aware that the reason I get hear for this is because it’s inclusive of trans men, and some people have a problem with that. 3/
Read 11 tweets
1 Jul
This @NEJM paper on the safety of #COVID19 #vaccines during #pregnancy found no increased risk of miscarriage associated with vaccination.

So why is this person claiming that there was an 83% rate of miscarriage?

Short answer, a maths mistake... 🧵

nejm.org/doi/pdf/10.105… Image
*But first* I would like to make it really clear that almost all miscarriages happen because there was something wrong with the baby that made it unviable. 1/
You cannot avoid miscarriage by being a "more careful mom" and to suggest to someone who has had a miscarriage that they should have been more careful is just cruel. 2/
Read 19 tweets
30 Jun
Every day, I get emails from people who have noticed changes to their periods following the COVID vaccine. But we don't yet have enough information to know if this is really linked to the vaccine and, if so, how common it is. 2/
Since March, I have been saying "I'm sure someone is doing the kind of study that will find this out." I contacted some of the period tracking apps to see if they wanted to work with me on the kind of study that would find this out, but they weren't keen. 3/
Read 5 tweets

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