BREAKING🔔 The 3rd preprint from G2P-Japan - we elucidated the evolution and virological phenotype of #Lambda variant (aka C.37 lineage). Lambda is resistant to vaccine-induced antiviral immunity. Please retweet 1/3
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
Mutational anaysis showed that a large deletion in the N-terminal domain of the Lambda spike protein (246-253 residues) is responsible for the resiscence to neutralizing antibodies. 2/3
Moreover, #L452Q mutation in Lambda increases viral infectivity, like the case of #L452R mutation, a characteristic of #Delta. Our data suggest that 1) increasing viral infectivity and 2) evading antiviral immunity are crucial for the efficient spread in the human population 3/3
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