Another great #Delta study from #Singapore. Thanks to @graemeblake for pointing it out to me.
"PCR cycle threshold (Ct) values were similar between both vaccinated & unvaccinated groups at diagnosis, but viral loads decreased faster in vaccinated..."
Ct>30 almost a week earlier!
"PCR cycle threshold (Ct) values were similar between both vaccinated & unvaccinated groups at diagnosis, but viral loads decreased faster in vaccinated..."
Ct>30 almost a week earlier!
"Early, robust boosting of anti spike protein antibodies was observed in vaccinated patients, however, these titers were significantly lower against B.1.617.2 as compared with the wildtype vaccine strain."
medrxiv.org/content/10.110…
medrxiv.org/content/10.110…
Outcomes significantly attenuated!
"Vaccine-breakthrough patients were significantly more likely to be asymptomatic (28% vs. 9%) & if symptomatic, had fewer number of symptoms."
-> 53% of unvaccinated had pneumonia compared to only 21% of breakthroughs.
-> 20% vs. 2% required O2.
"Vaccine-breakthrough patients were significantly more likely to be asymptomatic (28% vs. 9%) & if symptomatic, had fewer number of symptoms."
-> 53% of unvaccinated had pneumonia compared to only 21% of breakthroughs.
-> 20% vs. 2% required O2.
"We could not evaluate the underlying immunologic mechanisms behind vaccine-BTI, e.g., diminished neutralizing antibody level or impaired cellular immunity... Should compare... vaccinated who develop BTI with those who do not, to elucidate underlying drivers of susceptibility."
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