Embarrassing. In 2 months Fauci & CDC went from the vaccinated don't need masks they can't spread the virus to vaccinated have the same amount of virus in the nasopharynx as the unvaccinated. They should install Twitter & follow 20 accounts to know what's going on in the world.
In the last couple of months there were several studies showing 40% lower viral load in vaccinated than the unvaccinated participants. While vaccine cheerleaders celebrated this data, since that was all pre-Delta, my reaction was:
While @CDCDirector is surprised now by their new unpublished data showing that virus can thrive in the airways of vaccinated, there were studies made months before (in addition to common logic & basic knowledge).
Unlike Pfizer & Moderna, AstraZeneca regularly tested its trial participants, so we could in December 2020 find out about the efficacy vs. asymptomatic infection. In case you are wondering, it showed 3.8% efficacy from AZ's SD regime but nobody cared then.
This study shows "that a lower antibody levels are needed for reduction of viral replication in the lower airway than in the UPPER airway." Confirming higher antibody levels are needed for reduction of viral replication in the UPPER airway. science.sciencemag.org/content/early/…
So, there were signs from which one could have concluded from the start that vaccinated people might still transmit the virus.
But, it has only now become a visible problem because #Delta's higher viral load coincided with waning Abs levels from Pfizer.
Point of this thread is to show there was enough proof against advising vaccinated to stop wearing masks. They can't claim now: "Well, who could have known?" There were many who knew. This was either incompetence or deliberate political deception. cnbc.com/2021/05/13/cdc…
Whatever the reason, that CDC public health recommendation from May jeopardized the vaccinated, their friends & families and worst of all contributed to the current wave. The vaccinated are mostly shielded from the worst outcomes but they added to the spread & can get #LongCovid.
The Washington Post obtained the internal CDC report confirming everything we already knew, but it's nice officials finally acknowledging it. The access to the link appears denied. CDC blundered; the sooner they admit it & release the report the better.
Most of our misunderstandings come from semantics, using absolute binaries, without subtleties, for complex problem. Saying, e.g., just vaccines 'protect', with no additional explanations, suggests 100%, which is as unscientific as anti-vaxxer saying they don't work at all.
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Those kind of positions are confrontational & destroy trust. When someone only says 'protect', I ask yes but HOW MUCH, AGAINST WHAT & HOW LONG? When someone says 'see, they don't work', I say they DO this much, against this & this long. I think that's how you build trust.
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Hopefully, data will soon clarify current confusions, as there are more & more fantastic studies.
I would say, correct me if I'm wrong, that Abs are still our best correlate for protection. There are likely better ones, but we can't yet qualify or quantify them.
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Since we are going to talk more & more about innate & adaptive immune memory, what #SARSCoV2 does to them, how it fools or beats them & what vaccines can or can't do about it, here is a pre-pandemic 2019 paper about innate & adaptive immune memory. sciencedirect.com/science/articl…
Since the beginnings of the pandemic, my gut feeling hypothesis was that #SARS2 can fool the innate immune system and haywire & wear out the adaptive immune system. Thus, our aging makes it more dangerous with time & reinfections would only accumulate of the damage.
Among other fascinating properties, that was the reason in my newsletter I called it a potential civilization killer & the virus from the future.
I lacked the expertise to prove it but my working assumption was to avoid it as much as we can. There is no good in #SARS2 infection.
The endemicity being forced on us is founded on a belief that the severity of #SARSCoV2 is due to novelty: once our immune system gets familiar with the virus, it will become benign, just like the other four "common cold" human coronaviruses (hCoVs). 1/
The linear progression of #COVID severity with age is explained by kids being freshly exposed to endemic hCoVs. That's, supposedly, why kids have mild #COVID outcomes, just like how hCoVs are now harmless for adults: they just aren't novel anymore. 2/
This thinking denies any special CONSTELLATION of properties of #SARSCoV2 (variants, ACE2 binding, wide viral tropism, syncytia, anosmia, brain infiltration...). Once we all get exposed to it several times by natural infection and/or vaccination, the pandemic will stop.
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"Vaccine’s efficacy in preventing any Covid-19 infection that causes even minor symptoms appeared to decline by an average of 6% every 2 months after administration. It peaked at more than 96% within 2 months of vaccination & slipped to 84% after 6 months" statnews.com/2021/07/28/eff…
"...from 2 months to <4 months, VE was 90.1% & from 4 months to the data cut-off, VE was 83.7%."
"...through the data CUT-OFF (MARCH 13, 2021)."
"The current report provides updated efficacy analyses conducted on cases accrued up to March 13, 2021."
They noticed waning pre-Delta!
Previous was a study of the safety & efficacy up to 6 months post-2nd dose (also included vs. Beta, but there was no Delta then).
This next is info related to the effect from the 3rd booster shot from the Pfizer's 2nd quarter earnings call.
HT @JJulhes!
I would laugh at this kind of incompetence by the leading scientists if it wasn't sad. They jeopardized the whole vaccination campaign with unnecessary overselling before.
"New data suggests that people who are vaccinated & have breakthrough infections... washingtonpost.com/health/2021/07…
...from the delta variant may have as much viral load as a person who is unvaccinated, which suggests they may be able to spread it to others, Walensky said."
"Vaccinated people are transmitting it & the extent is unclear but there’s no doubt they’re transmitting it,” Fauci said.
Fauci now: "People who are vaccinated, even when they’re asymptomatic, can transmit the virus."
I, a layman, a trader, in December 2020, after carefully reading Pfizer's study protocol & FDA briefing:
One of the most uniquely disruptive things about the #SARSCoV2 pandemic is the extreme disproportionality of outcomes, which leads to insurmountable divisions & misunderstandings on all levels, threatening to rupture society. 1/ diaryofamacrodaytrader.substack.com/p/3-disproport…
I wrote about this #COVID characteristic last year. Some might experience only mild symptoms; others get excruciatingly stuck in hospital for months. Some families decimated; others barely felt it.
It takes a lot of empathy to envision & feel pain outside of a person's circle.
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Disproportionate outcomes are further amplified across age groups & according to health & wealth. #SARS2 finds any weakness. Mortality skyrockets once people can't get oxygen.
When we get to a national level, these same divisions & misunderstandings show up again.
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