Thread by @IoanaA_Cristea

Bashing #metaanalysis is as fashionable as ever, as always with hands up in the air. In response to a thread moaning the lack of added value of meta-analyses over individual studies, I realized I know of *many* meta-analyses that literally overturned whole fields.

So I want to start my alternative thread, in which instead the of the same old lamets, we list consequential meta-analyses in #Mentalhealth, which definitely provided more information than each and any single individual study.

These don't have to be methodologically flawless, because no study is. They do have to have a decent quality (which is much less of an elusive construct than oft presented). I will start with a few and update when I have time. Feel free to add to the collection. Order random.

Barth, Munder, Gerger et al network meta-analysis demonstrating minor differences between psychotherapies for depression.
(Updated by @pimcuijpers et al this year with similar results)
journals.plos.org/plosmedicine/a…
onlinelibrary.wiley.com/doi/full/10.10…

Smit, Huibers, Ioannidis, et al.on the (lack of) effectiveness of long-term psychoanalytic psychotherapy, followed by a flurry of re-analyses, comments etc.
pubmed.ncbi.nlm.nih.gov/22227111/

.@Toshi_FRKW et al showing that the waitlist might actually be harmful for the treatment of depression:
pubmed.ncbi.nlm.nih.gov/24697518/

My good friend @NaudetFlorian flipping network meta-analysis on its head by seemingly differential efficacy of placebos (yes, this means that you can use the method in an elegant way to show limitations of the method, which I think trump Twitter rants)
bmcmedicine.biomedcentral.com/articles/10.11…

.@Toshi_FRKW et al. on dismantling internet-based CBT for depression, using the most sophisticated IMO approach yet that combines component network meta-analysis with individual patient data:
pubmed.ncbi.nlm.nih.gov/33957075/

Stafford, Jackson & @EvanMayoWilson on early intervention to prevent or delay transition to psychosis:
bmj.com/content/346/bm…

Leucht et al in a perspective-changing meta-analysis comparing the efficacy of general medicine and psychiatric medication.
cambridge.org/core/journals/…
(And our citation analysis showing how the message was distorted: pubmed.ncbi.nlm.nih.gov/29183418/

.@eturnermd1 et al on selective publication of antidepressants, with a demonstration of the impact on apparent efficacy
nejm.org/doi/full/10.10…