Who's been waiting for UK data on the safety of #COVID19 #vaccines in #pregnancy? 💉🤰🏽🇬🇧🤔

🙋🏻‍♀️

Well now we have some!

(TLDR: No concerns arising from this study)... 🧵

ajog.org/article/S0002-…
This study looked at people coming to give birth at St George's hospital in London between March 1st and July 4th 2021.

141 had had at least one dose of a COVID vaccine

1187 were unvaccinated. 2/
(And for those always on the hunt for data about the AstraZeneca vaccine in pregnancy... 13 of the vaccinated people had had AZ.) 3/
The authors took 133 of the ppl who had had COVID vaccine and matched them (for age, ethnicity, measures of deprivation, antenatal medication and pre-pregnancy diabetes) with 399 ppl who were not vaccinated.

(8 of the vaccinated ppl were left out because they had no match). 4/
They found no difference in

👉🏻stillbirth
👉🏻fetal abnormalities
👉🏻small for gestational age
👉🏻maternal or neonatal intensive care admission
👉🏻birth < 40 weeks

between the vaccinated and unvaccinated groups. 5/
It's only mostly good news, because it means I have had to update my single slide summary *already*! 😉

6/6
PS. I would really like to thank author of this paper @kalafaterkan_md for sending it to me when it was hot off the press!

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More from @VikiLovesFACS

19 Jul
After I wrote this thread about the potential effects of COVID vaccination in pregnancy and the lack of such effects in other vaccines, perinatal epidemilogist @deshaynef got in touch to tell me about some work she has done in this area... 🧵
Her group has published two papers doing 3-5 year follow-up on the babies of people vaccinated against flu in pregnancy.

👉 Flu vaccination in pregnancy was not associated with adverse outcomes in children later on. 2/
Read 5 tweets
19 Jul
"I'm #pregnant and I want to get the #COVID19 #vaccine to protect myself and my baby. But should I wait until after 12 weeks?"

🧵...
Two studies have looked at pregnancy-specific adverse events following COVID-19 vaccination in the first trimester of pregnancy.

Both found no increased risk of miscarriage.... 2/

nejm.org/doi/full/10.10…

jamanetwork.com/journals/jama/…
The other thing that is a theoretical worry in the first trimester is a high fever (more than 39C for more than 24h) affecting the baby's development.

Although mild fevers are a common side-effect of vaccination, a fever as severe as this is really uncommon... 3/
Read 11 tweets
16 Jul
A question I get asked *a lot* is…

“What are the long-term effects on babies born after #COVID19 #vaccination in #pregnancy?”

So let’s talk about what we know… 🧵
Let’s start by looking at the effects at birth. We now have four large datasets from three countries telling us that babies born after vaccination in pregnancy are normal. 2/

USA

nejm.org/doi/full/10.10…

medrxiv.org/content/10.110…
Read 12 tweets
15 Jul
Lots of ppl are asking about this article in the Daily Mail. The headline implies we have no idea if the Moderna #COVID19 #vaccine is safe in #pregnancy, despite 1000's having had it.

We actually know that it's safe *because* 1000's have had it... 🧵

dailymail.co.uk/health/article…
Pregnant people were not included in the first rounds of the clinical trials. However, following good safety and efficacy results in the first rounds, both Pfizer and Janssen quickly extended their trials into this group. 2/
Pfizer's trial in pregnant people started in February, and Janssen's in March, both without much fanfare. This is simply Moderna following suit. 3/
Read 16 tweets
14 Jul
Periodically, I get a lot of heat for using gender neutral phrases like “pregnant people” or “people who have periods” rather than “women”.

So today, I’d like to take a few moments to explain why I do that, including some of my more personal reasons… 🧵
But let’s start by being clear that women are people!

So these phrases include pregnant women and women who have periods. 2/
Second, I am aware that the reason I get hear for this is because it’s inclusive of trans men, and some people have a problem with that. 3/
Read 11 tweets
1 Jul
This @NEJM paper on the safety of #COVID19 #vaccines during #pregnancy found no increased risk of miscarriage associated with vaccination.

So why is this person claiming that there was an 83% rate of miscarriage?

Short answer, a maths mistake... 🧵

nejm.org/doi/pdf/10.105… Image
*But first* I would like to make it really clear that almost all miscarriages happen because there was something wrong with the baby that made it unviable. 1/
You cannot avoid miscarriage by being a "more careful mom" and to suggest to someone who has had a miscarriage that they should have been more careful is just cruel. 2/
Read 19 tweets

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