COVID-19 NEWS: A new analysis of data (not yet peer-reviewed) from the Moderna #COVID19 vaccine Ph 3 trial adds evidence toward establishing a "correlate of protection"—a measurable marker of efficacy used to predict whether a vaccine will be protective bit.ly/CoP1273
The data indicate levels of neutralizing antibody responses strongly correlate with protection against symptomatic COVID-19. 4 kinds of tests showed that higher antibody levels correlated with higher estimated vaccine efficacy against symptomatic COVID-19.
Correlates of protection can help speed regulatory authorization & approval. Instead of large trials, samples from smaller groups of vaccinated people could be evaluated with a test indicating whether a vaccine is likely to have clinical benefit in that population.
Experts from #NIAID, @BARDA, @fredhutch & partner institutions conducted the research as part of a coordinated effort to identify correlates using data from federally supported Ph. 3 clinical trials of COVID-19 vaccines.
The analysis builds on peer-reviewed research in animal models, published in @ScienceMagazine
https://twitter.com/ScienceMagazine/status/1422447152412962830.
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