Hi #medtwitter #neurotwitter #medstudenttwitter #meded #FOAMed

It's been too long since my last #EndNeurophobia #tweetorial. As requested by @sukritibanthiya here is a tweetorial on MUSCLE DISEASE (MYOPATHY)

Let me know what you think and what I should cover next!
Classic pattern of weakness in myopathy is PROXIMAL symmetric weakness of the limbs, though there are exceptions.

There should be NO sensory findings (unless there is concurrent neuropathy) and reflexes are often spared until the patient is extremely weak.
Difficulty rising from a chair (hip girdle musculature), washing hair (shoulder girdle musculature)

CK is often elevated but not always

EMG can demonstrate myopathic pattern (though can be normal eg statin myopathy)

Definitive Dx may require muscle biopsy and/or genetic test
There are so many causes of myopathy.
I divide into 5 broad categories to consider:

INFLAMMATORY

GENETIC

SECONDARY TO SYSTEMIC DISEASE

TOXIC

INFECTIOUS
INFLAMMATORY:
In med school, I learned 2:
Dermatomyositis (DM) & Polymyositis (PM)
Both with proximal weakness

Dermato with skin findings (mechanic hands, Gottron papules, V sign on neck, shawl sign on back heliotrope rash of eyelids), a/w malignancy

Different findings on path
In residency, I learned:
Inclusion body myositis (IBM): weakness long finger flexors, quads, dorsiflexion; dysphagia, asymmetry may occur; more common in men>50), may be a/w T cell large granular lymphocytic leukemia.

Immune-mediated necrotizing: may/may not be statin-induced
This keeps getting more complicated as more antibodies are discovered that correlate w/particular syndromes:

DM: Anti-MDA-5, Mi-2, SAE, NXP-2, TIF-1 (last 2 a/w ⬆️ risk malignancy)

IBM: anti-cytoplasmic 5’-nucleotidase 1A

Immune-mediated necr: anti-HMG CoA reductase, anti-SRP
Anti-synthetase syndrome: anti-Jo-1, PL-7, PL-12 a/w myositis, mechanic’s hands, Raynaud phenomenon, arthritis, and interstitial lung disease

Colleagues tell me they’re not even sure PM exists as a unique entity anymore…

Most inflam myop respond to immunomod; IBM doesn't
GENETIC

I divide these into:

DYSTROPHIES: mutations in muscle proteins

METABOLIC: mutations in metabolic pathways

MITOCHONDRIAL: mutations in mitochondrial genes

PERIODIC PARALYSES: mutations in ion channels
DYSTROPHIES

Duchenne, Becker, Fascioscapulohumeral, Limb-Girdle, Oculopharyngeal, Myotonic, Emery-Dreifuss, Distal dystrophies...

Names mostly explain sites of weakness

Many have cardiac involvement

E-D has prominent contractures
Distal dystrophies
Rare and break “myopathy = proximal” rule. They present almost all with DORSIFLEXION weakness, though Miyoshi affects plantarflexion, and Welander also affects the hands.

I’ve never seen any of these outside of conference presentations and text books.
Want to look smart and rattle these off @ a conference?Here’s a mnemonic:
U
M
L M N + W
Of course they don’t affect UMN or LMN, but just mnemonic. MiyOshi affects gastrOc, LaiNg the neck, WelANDer the hAND.

Thought these would be on the boards. They weren’t.
Metabolic myopathies
The one for adult neurologists to know is adult-onset Pompe disease (acid maltase deficiency) as it may not have the exercise-induced symptoms of the others and present simply w/proximal weakness–and it’s treatable w/enzyme replacement!
Mitochondrial myopathy:
Often other features of multi-system disease.
If you see epilepsy + myopathy, think mitochondrial, e.g., MERRF (myoclonic epilepsy w/ragged red fibers), mutation in A8344G (I remember the RR - 44 for the boards)
PERIODIC PARALYSES
I’ve never seen these in real life. But would be a diagnosis to consider if a patient becomes paralyzed after a high carb meal (hypoK periodic paralysis) or fasting/exercise (hyperK periodic paralysis) and has abnormal K on BMP
SYSTEMIC DISEASES

Rheumatologic disease (lupus, systemic sclerosis): called overlap myopathy (anti-Ku, anti-PMScl, and anti-U1 RNP may be seen)

Endocrine (hypo/hyperthyroid, Cushing's (intrinsic or iatrogenic)

Critical illness myopathy
INFECTIONS

Viral (HIV)

Parasitic: trichinosis (affecting face/eye muscles), toxo, cysticercosis (usually asymptomatic)

Bacterial: muscle abscess/pyomyositis.
MEDICATIONS

*STATINS*: anything from asymptomatic ⬆️CK to acute necrotizing myopathy. Higher dose, older age, concurrent fibrates increase risk

Immunomodulatory therapies (steroids, chloroquine, colchicine, cyclosporine, tacrolimus)
Checkpoint inhibitors
Amiodarone
Zidovudine
OK, what did I miss @CrystalYeoMDPhD ?

Want more tweetorials?twitter.com/i/events/12671…

#EndNeurophobia 🧠❤️

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Hello, #MedTwitter, #MedStudentTwitter, #NeuroTwitter
It’s been a long time since my last clinical neuroanatomy #tweetorial, sorry about that!

Here's a new one:

MOTOR SUPPLY to the FACE and Approach to FACIAL WEAKNESS

cc @Tracey1milligan @CPSolvers @DxRxEdu @MedTweetorials
I'm glad #EndNeurophobia campaign has grown but please check out the rest of my feed, which seeks to amplify voices I’m learning from on the path to becoming an antiracist ally
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Just like the arms and legs the facial motor pathway has both UPPER motor neurons and LOWER motor neurons:
The UMNs begin in the lateral precentral gyrus, descend with the internal capsule, through the cereeral peduncle to arrive at the facial nucleus in the PONS.
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