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Classic pattern of weakness in myopathy is PROXIMAL symmetric weakness of the limbs, though there are exceptions.
There should be NO sensory findings (unless there is concurrent neuropathy) and reflexes are often spared until the patient is extremely weak.
Difficulty rising from a chair (hip girdle musculature), washing hair (shoulder girdle musculature)
CK is often elevated but not always
EMG can demonstrate myopathic pattern (though can be normal eg statin myopathy)
Definitive Dx may require muscle biopsy and/or genetic test
There are so many causes of myopathy.
I divide into 5 broad categories to consider:
INFLAMMATORY
GENETIC
SECONDARY TO SYSTEMIC DISEASE
TOXIC
INFECTIOUS
INFLAMMATORY:
In med school, I learned 2:
Dermatomyositis (DM) & Polymyositis (PM)
Both with proximal weakness
Dermato with skin findings (mechanic hands, Gottron papules, V sign on neck, shawl sign on back heliotrope rash of eyelids), a/w malignancy
Different findings on path
In residency, I learned:
Inclusion body myositis (IBM): weakness long finger flexors, quads, dorsiflexion; dysphagia, asymmetry may occur; more common in men>50), may be a/w T cell large granular lymphocytic leukemia.
Immune-mediated necrotizing: may/may not be statin-induced
This keeps getting more complicated as more antibodies are discovered that correlate w/particular syndromes:
Distal dystrophies
Rare and break “myopathy = proximal” rule. They present almost all with DORSIFLEXION weakness, though Miyoshi affects plantarflexion, and Welander also affects the hands.
I’ve never seen any of these outside of conference presentations and text books.
Want to look smart and rattle these off @ a conference?Here’s a mnemonic:
U
M
L M N + W
Of course they don’t affect UMN or LMN, but just mnemonic. MiyOshi affects gastrOc, LaiNg the neck, WelANDer the hAND.
Thought these would be on the boards. They weren’t.
Metabolic myopathies
The one for adult neurologists to know is adult-onset Pompe disease (acid maltase deficiency) as it may not have the exercise-induced symptoms of the others and present simply w/proximal weakness–and it’s treatable w/enzyme replacement!
Mitochondrial myopathy:
Often other features of multi-system disease.
If you see epilepsy + myopathy, think mitochondrial, e.g., MERRF (myoclonic epilepsy w/ragged red fibers), mutation in A8344G (I remember the RR - 44 for the boards)
PERIODIC PARALYSES
I’ve never seen these in real life. But would be a diagnosis to consider if a patient becomes paralyzed after a high carb meal (hypoK periodic paralysis) or fasting/exercise (hyperK periodic paralysis) and has abnormal K on BMP
SYSTEMIC DISEASES
Rheumatologic disease (lupus, systemic sclerosis): called overlap myopathy (anti-Ku, anti-PMScl, and anti-U1 RNP may be seen)
Endocrine (hypo/hyperthyroid, Cushing's (intrinsic or iatrogenic)
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I will focus on the condition/neurology, not the possible association w/vaccine or hematology. I leave that to experts like @shemarmoore and her excellent thread here:
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I had the incredible good fortune to meet Carola about 15 years ago. She was auditing a music class that I was a TA for. She said she'd heard I had dropped out of med school to be a musician and as a retired psychiatrist she would like to get to know me.
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Just like the arms and legs the facial motor pathway has both UPPER motor neurons and LOWER motor neurons:
The UMNs begin in the lateral precentral gyrus, descend with the internal capsule, through the cereeral peduncle to arrive at the facial nucleus in the PONS.