Thread by @DrEricDing

BREAKING—lower dose of the Pfizer-BioNTech #COVID19 vaccine — one-third the amount given to adults and teens — is safe and triggered a robust immune response in children 5-11 years old. Data submission to FDA end of September—hopeful for EUA in October. 🧵
washingtonpost.com/health/2021/09…

2) With the school year in full swing and cases soaring among children, pediatricians have been inundated with requests to bend the rules and give children a shot now, under off-label use (allowed for Pfizer via FDA rules since fully approved). washingtonpost.com/health/pediatr…

3) The step forward for a children’s vaccine may deepen the rift between families eager for the vaccine and parents who are hesitant. Hospitalizations among children have increased in the delta surge. washingtonpost.com/health/2021/08…

4) “children 5 to 11 years of age using a two-dose regimen of 10 µg administered 21 days apart, a smaller dose than the 30 µg dose used for people 12 and older. The antibody responses comparable to those in 16 to 25 years of age immunized with 30 µg. businesswire.com/news/home/2021…

5) “The data enrolling children 6 months to 11 years of age, was for 2,268 participants who were 5 to 11 years of age and received a 10 µg dose level in a two-dose regimen. In the trial, the SARS-CoV-2–neutralizing antibody geometric mean titer (GMT) was 1,197.6…”

6) “…demonstrating strong immune response in this cohort of children one month after the second dose. This compares well (was non-inferior) to the GMT of 1146.5 from participants ages 16 to 25 years old

7) “Further, the COVID-19 vaccine was well tolerated, with side effects generally comparable to those observed in participants 16 to 25 years of age.”

8) LET THIS SINK IN— Children now account for more than one in five new cases, and the highly contagious Delta variant has sent more children into hospitals and intensive care units in the past few weeks than at any other time in the pandemic. nytimes.com/live/2021/09/2…

9) kids are the coronavirus reservoirs now. We need to vaccinate all kids and give boosters to all adults over 6 months since 2nd shot ASAP.

https://twitter.com/drericding/status/1439986043080658949