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me64 陳美滿 Profile picture
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29 Sep, 5 tweets, 3 min read
Variant that could potentially affect more people who are vaccinated against COVID-19.
#Vaccine creates #variants

#Nsp12 #W152L #C241U Mutations

Also found in all VOCs #P323L and #D614G mutations.

"What Is the R.1 COVID-19 Variant? What We Know So Far" health.com/condition/infe…
Orf9c
N proteins
S proteins
"SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells"

"Our study indicated that ORF9c enables immune evasion and coordinates cellular changes essential for the SARS-CoV-2 life cycle."

biorxiv.org/content/10.110…

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More from @mega_pindang71

me64 陳美滿 Profile picture
22 Sep
Five of nine C19 positive pregnant women, have same lesions in the placenta.

That’s 55,55%.

“These placentas showed lesions characterized by villous trophoblast necrosis with intervillous space collapse and..
nature.com/articles/s4137…
variable amounts of mixed intervillous inflammatory infiltrate and perivillous fibrinoid deposition.”
"Such lesions ranged from focal to massively widespread in five cases, resulting in intrauterine fetal death."
Read 7 tweets
me64 陳美滿 Profile picture
3 Sep
"Although it is rare with vaccination, the COVID-19 vaccine is likely the cause of hepatotoxicity in our patient based on a diagnosis of exclusion. In this

Cureus | Drug-Induced Liver Injury After COVID-19 Vaccine cureus.com/articles/63877…
case, the patient had a cholestatic pattern with elevated ALP and bilirubin with mild elevation in the transaminases."

Based on population-based studies, drug-induced liver injury incidence varies between 13.9 and 19.1 cases per 100,000 people per year.

From the spontaneous
reports from patients who received Pfizer/BioNTech BNT162b2 mRNA in the UK between 9/12/20 and 26/05/2021, there are reports of 45 patients having abnormal liver function analysis and three patients having drug-induced liver injury.
Read 6 tweets
me64 陳美滿 Profile picture
27 Aug
Dr. Peter McCullough & Dr. Al Johnson
COVID questions. A 🧵.
The vaccines are failing against Delta Variant (DV).
All of us esp parents and teacher need to pay attention to the symptoms. Early treatment are the best, don't wait for the PCR. If a kid has symptoms,
get him out of school, put him in his bedroom with windows open. Early test: antigen test. Kids should not be vaccinated, give them Vit C Vit D, Zn, polyphenol supplements e.g. Quercetin. Aspirin for fever. Check aapsonline.org/covidpatientgu…
Oral hygiene : Brush your teeth with original Yellow Listerine is effective to kill virus in the mouth. Dilute H2O2 or NaOCL, or Povidone iodine are also good.
Nasal hygiene is a good prophylaxis too.

Once patient in the hospital.
mAbs (Regeneron) is effective,
Read 10 tweets
me64 陳美滿 Profile picture
27 Aug
Lambda variant.
"Bamlanivimab FULLY LOST BINDING
toLambdavariant.
Structural modeling ofcomplexesofRBD-human receptor, ACE2, andBamlanivimab suggest the potentialbasisofthe
change of binding."
biorxiv.org/content/10.110…
This could be the possible link of : mAbs can challenge the virus to mutate into a newer variant.

"Overall antibodies fromPfizer-BioNTech vaccinated individuals drop dramatically ( ~ 4.0times for lambda)after sixmonths."
"F490SandL451Qleadtothe disruptionsofa hydrophobic patch,whichisacriticalareaforthe bindingofbroadlyneutralizing
antibodies."
Read 9 tweets
me64 陳美滿 Profile picture
11 Aug
Polysorbate 80, also present in Moderna C19 vac.
PS80 delays the inhibition of thermal aggregation process of insulin. Addition of PS80 leads to an increase in beta-sheet structure and concomitant altered morphology and ...
#betaamyloid
#protein
#aggregation
enhanced stability of the formed spherulites. This may impact safety and efficacy of the protein drugs product.
Read 7 tweets
me64 陳美滿 Profile picture
10 Aug
The receptors involved in SARS-CoV-2 infection are co-expressed in the cells of the NVU, especially in astrocytes and microglial cells. These receptors are functionally active as exposure of endothelial cells to the SARS CoV-2 S1 protein subunit ..
#HIV
#ACE2
#brain
altered the expression pattern of tight junction proteins, such as claudin-5 and ZO-1. Additionally, HIV-1 infection upregulated ACE2 and TMPRSS2 expression in brain astrocytes and microglia cells.
#astrocytes
#microglia
#brain
SC2 in BBB mechanism. Image
Read 10 tweets

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