studied chemical eng,
Dec 12, 2021 • 23 tweets • 7 min read
A 🧵about 🧠problems after C19 💉
1. Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection.
“There was an increased risk of Guillain–Barré syndrome and Bell’s palsy with ChAdOx1nCoV-19, hemorrhagic stroke with BNT162b2. ..An independent
Scottish cohort provided further support for the association between ChAdOx1nCoV and Guillain–Barré syndrome, there was a substantially higher risk of all neurological outcomes in the 28 days after a positive SARS-CoV-2 test including Guillain–Barré syndrome. Overall, we
Nov 23, 2021 • 14 tweets • 6 min read
Thyroid as a #target of adjuvant #autoimmunity /#infammatory syndrome due to mRNA‐based SC2 vaccination. #Vaccines contain #adjuvants which are not exempt from adverse efects and can #trigger the autoimmune/infammatory syndrome induced by adjuvants (#ASIA).
Multiple endocrine organs have receptors for ACE2.
mRNA of ACE2, the SARS-CoV2 receptor, is expressed in the thyroid cells.
ACE2 receptor is abundantly expressed by the thyroid. Elevated levels of proinflammatory cytokines could increase the expression ofACE2 on the thyroidgland.
Nov 9, 2021 • 8 tweets • 3 min read
Road to #Paxlovid#Pfizer#COVID19 new drug. pubmed.ncbi.nlm.nih.gov/34029993/
3CLpro inhibitors commonly target host proteases, which presents a potential liability for unexpected side effects.
Challenges : enzyme inhibition was only achieved in the absence of physiologically relevant reducing agents, and the reported antiviral effect in cells infected with SARS-CoV-2 could not be reproduced and was therefore suspected to be an indirect consequence of cell death.
Nov 9, 2021 • 22 tweets • 6 min read
The Road to Paxlovid (PF-07321332)
A thread. #paxlovid#protease#inhibitors#ivermectin#COVID19
Dr. John Campbell: Paxlovid vs Ivermectin
New Pfizer antiviral and ivermectin, a pharmacodynamic analysis. Paxlovid (PF-07321332), C₂₃H₃₂F₃N₅O₄
Paxlovid is designed to block the activity of the SARS-CoV-2-3CL protease, an enzyme that the coronavirus needs to replicate. Co-administration with a low dose of
Nov 9, 2021 • 6 tweets • 2 min read
February 15 and August 15, 2021 C19 Vaccination during Pregnancy & First-Trimester Miscarriage
March 2019 Norway study.
PLpro has an implication in viral invasion by shutting down the viral-induced host innate immune response. Dihydrotanshinone I appears to be the strongest inhibitor amongst the tanshinone ..1/n
derivatives. It is a natural compound isolated from lipophilic fraction of Salvia miltiorrhiza, which has a long history in traditional Chinese medicine. Several derivatives of tanshinones were previously reported to be inhibitors for SARS-CoV-1 PLpro and to a lesser extent ..2/n
Nov 8, 2021 • 12 tweets • 3 min read
SC2 MPro inhibitors alternatives, plant flavonoids. 1/n #MPro#SARSCoV2#inhibitor
Kaempferol, Quercetin, and Rutin
were able to bind at the substrate binding pocket of 3CLpro with high affinity and interact with the active site residues .. chemrxiv.org/engage/chemrxi…
such as His41 and Cys145 through hydrogen bonding and hydrophobic interactions. In fact, the binding affinity of Rutin was much higher than Chloroquine (1000 times) and Hydroxychloroquine (100 times) and was comparable to that of the reference drug Remdesivir. 2/n
Nov 8, 2021 • 8 tweets • 4 min read
In silico identification of natural products from Centella asiatica as SARS-COV-2 main protease (M pro) inhibitor. 1/n
Comparison of SARS-CoV-2 Receptors Expression in Primary Endothelial Cells and Retinoic Acid-Differentiated Human Neuronal Cells #TMPRSS2#NRP1#ACE2 levels increase when cells are treated with #retinoicacid (RA). #ACE2 and #TMPRSS2 expression in subsets of lung epithelial cells
are regulated by androgen-signaling. #NRP1 is highly expressed in the respiratory and olfactory epithelium, which can explain the SC2 infectivity and spreading through both the lungs and olfactory bulb. NRP1 is involved in axonal guidance and pruning. Data indicate that
Nov 2, 2021 • 5 tweets • 3 min read
Monoclonal Human Antibodies That Recognise the Exposed N and C Terminal Regions of the Often-Overlooked SARS-CoV-2 ORF3a Transmembrane Protein
Serum samples, nasopharyngeal and oropharyngeal swabs of persons who are homeless and shelter workers collected from August 25th-27th, 2020 were tested for the presence of anti-SC2 IgM and IgG antibodies by ELISA and SARS-CoV-2 RNA by RT-qPCR, respectively. 2/n
Oct 16, 2021 • 7 tweets • 3 min read
Potential Cause of COVID-19 ‘Long-haulers’ : antibodies specific for ACE2.
Ivermectin 0.2-0.4mg/kg works at the outer and inner part of cells, thru P2X, GlycineCls, has anti-inflammatory effects, proven for decades, etc.
Molnupiravir 800mg twice a day for 5 days, works thru the RdRp. Can this antiviral have the side effects similar to Remdesivir ?
Five of nine C19 positive pregnant women, have same lesions in the placenta.
“These placentas showed lesions characterized by villous trophoblast necrosis with intervillous space collapse and.. nature.com/articles/s4137…
variable amounts of mixed intervillous inflammatory infiltrate and perivillous fibrinoid deposition.”
Sep 3, 2021 • 6 tweets • 1 min read
"Although it is rare with vaccination, the COVID-19 vaccine is likely the cause of hepatotoxicity in our patient based on a diagnosis of exclusion. In this
Cureus | Drug-Induced Liver Injury After COVID-19 Vaccine cureus.com/articles/63877…
case, the patient had a cholestatic pattern with elevated ALP and bilirubin with mild elevation in the transaminases."
Based on population-based studies, drug-induced liver injury incidence varies between 13.9 and 19.1 cases per 100,000 people per year.
From the spontaneous
Aug 27, 2021 • 10 tweets • 2 min read
Dr. Peter McCullough & Dr. Al Johnson
COVID questions. A 🧵.
The vaccines are failing against Delta Variant (DV).
All of us esp parents and teacher need to pay attention to the symptoms. Early treatment are the best, don't wait for the PCR. If a kid has symptoms,
get him out of school, put him in his bedroom with windows open. Early test: antigen test. Kids should not be vaccinated, give them Vit C Vit D, Zn, polyphenol supplements e.g. Quercetin. Aspirin for fever. Check aapsonline.org/covidpatientgu…
Aug 27, 2021 • 9 tweets • 2 min read
"Bamlanivimab FULLY LOST BINDING
Structural modeling ofcomplexesofRBD-human receptor, ACE2, andBamlanivimab suggest the potentialbasisofthe change of binding." biorxiv.org/content/10.110…
This could be the possible link of : mAbs can challenge the virus to mutate into a newer variant.
"Overall antibodies fromPfizer-BioNTech vaccinated individuals drop dramatically ( ~ 4.0times for lambda)after sixmonths."
Aug 11, 2021 • 7 tweets • 2 min read
Polysorbate 80, also present in Moderna C19 vac.
PS80 delays the inhibition of thermal aggregation process of insulin. Addition of PS80 leads to an increase in beta-sheet structure and concomitant altered morphology and ... #betaamyloid #protein #aggregation
enhanced stability of the formed spherulites. This may impact safety and efficacy of the protein drugs product.
Aug 10, 2021 • 10 tweets • 4 min read
The receptors involved in SARS-CoV-2 infection are co-expressed in the cells of the NVU, especially in astrocytes and microglial cells. These receptors are functionally active as exposure of endothelial cells to the SARS CoV-2 S1 protein subunit .. #HIV #ACE2 #brain
altered the expression pattern of tight junction proteins, such as claudin-5 and ZO-1. Additionally, HIV-1 infection upregulated ACE2 and TMPRSS2 expression in brain astrocytes and microglia cells. #astrocytes #microglia #brain