Ivermectin 0.2-0.4mg/kg works at the outer and inner part of cells, thru P2X, GlycineCls, has anti-inflammatory effects, proven for decades, etc.
Molnupiravir 800mg twice a day for 5 days, works thru the RdRp. Can this antiviral have the side effects similar to Remdesivir ?
Comparison studies about Molnupiravir.
Gordon et al. : the high frequencies of G-to-A and C-to-U transition mutations in coronaviruses exposed to molnupiravir.

#host DNA #mutagenesis possibility

Kabinger et al. entertains A-to-G transitions, which can occur in coronaviruses exposed to molnupiravir, albeit at much lower frequencies.

Thus, although the biochemical evidence indicates that molnupiravir triphosphate (MTP)
is a better CTP (natural nucleotide) analog, the ..
genetic data suggest that MTP can compete weakly with UTP, inducing A-to-G transitions.
Sheahan et al. did not observe mutagenesis of host (us, human) mRNA.
It has been suggested that exposure to molnupiravir can be mutagenic to host DNA during host DNA replication.

#host #human #DNA #mutagenesis

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More from @mega_pindang71

29 Sep
Variant that could potentially affect more people who are vaccinated against COVID-19.
#Vaccine creates #variants

#Nsp12 #W152L #C241U Mutations

Also found in all VOCs #P323L and #D614G mutations.

"What Is the R.1 COVID-19 Variant? What We Know So Far" health.com/condition/infe…
N proteins
Read 5 tweets
22 Sep
Five of nine C19 positive pregnant women, have same lesions in the placenta.

That’s 55,55%.

“These placentas showed lesions characterized by villous trophoblast necrosis with intervillous space collapse and..
variable amounts of mixed intervillous inflammatory infiltrate and perivillous fibrinoid deposition.”
"Such lesions ranged from focal to massively widespread in five cases, resulting in intrauterine fetal death."
Read 7 tweets
3 Sep
"Although it is rare with vaccination, the COVID-19 vaccine is likely the cause of hepatotoxicity in our patient based on a diagnosis of exclusion. In this

Cureus | Drug-Induced Liver Injury After COVID-19 Vaccine cureus.com/articles/63877…
case, the patient had a cholestatic pattern with elevated ALP and bilirubin with mild elevation in the transaminases."

Based on population-based studies, drug-induced liver injury incidence varies between 13.9 and 19.1 cases per 100,000 people per year.

From the spontaneous
reports from patients who received Pfizer/BioNTech BNT162b2 mRNA in the UK between 9/12/20 and 26/05/2021, there are reports of 45 patients having abnormal liver function analysis and three patients having drug-induced liver injury.
Read 6 tweets
27 Aug
Dr. Peter McCullough & Dr. Al Johnson
COVID questions. A 🧵.
The vaccines are failing against Delta Variant (DV).
All of us esp parents and teacher need to pay attention to the symptoms. Early treatment are the best, don't wait for the PCR. If a kid has symptoms,
get him out of school, put him in his bedroom with windows open. Early test: antigen test. Kids should not be vaccinated, give them Vit C Vit D, Zn, polyphenol supplements e.g. Quercetin. Aspirin for fever. Check aapsonline.org/covidpatientgu…
Oral hygiene : Brush your teeth with original Yellow Listerine is effective to kill virus in the mouth. Dilute H2O2 or NaOCL, or Povidone iodine are also good.
Nasal hygiene is a good prophylaxis too.

Once patient in the hospital.
mAbs (Regeneron) is effective,
Read 10 tweets
27 Aug
Lambda variant.
Structural modeling ofcomplexesofRBD-human receptor, ACE2, andBamlanivimab suggest the potentialbasisofthe
change of binding."
This could be the possible link of : mAbs can challenge the virus to mutate into a newer variant.

"Overall antibodies fromPfizer-BioNTech vaccinated individuals drop dramatically ( ~ 4.0times for lambda)after sixmonths."
"F490SandL451Qleadtothe disruptionsofa hydrophobic patch,whichisacriticalareaforthe bindingofbroadlyneutralizing
Read 9 tweets
11 Aug
Polysorbate 80, also present in Moderna C19 vac.
PS80 delays the inhibition of thermal aggregation process of insulin. Addition of PS80 leads to an increase in beta-sheet structure and concomitant altered morphology and ...
enhanced stability of the formed spherulites. This may impact safety and efficacy of the protein drugs product.
Read 7 tweets

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