But why would anyone even think that such a thing might happen? Is it even worth researching?
The rumours that COVID19 vaccines would impact fertility were started by a vaccine skeptic who proposed that this might occur, so this is something that a lot of ppl may have heard. 2/
People who work in this area never thought this was very likely, for a number of reasons.
Not least, if this did happen COVID π¦ would be associated with infertility or problems in early pregnancy, and luckily we donβt see that. 3/
This new study has been peer-reviewed and uses a slightly cleaner assay, which makes the results clearer.
ππ» Antibodies from vaccinated people bind to COVID19 spike protein (as expected), but not to syncytin-1. 5/
They also took a look at antibodies from people who had been infected with COVID19 π¦ . They also bind to COVID19 spike protein, but not to syncytin-1. 6/
So can we please put to bed this idea that #COVID19#vaccines can raise an immune response to syncytin-1, harming #fertility?
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Letβs start by looking at the effects at birth. We now have eight large datasets from four countries looking at almost 79,000 people vaccinated in pregnancy. The outcomes for the babies are all normal. 2/
(The CDC has recently put out data from 2 more US studies, bringing the total to 10. But there is some overlap between the participants in these studies and the ones quoted above, so I didn't add those in as unique participants.)
Why is effectiveness vs hospitalisation lower than against all infection? This is the opposite of what we see in larger studies of the whole population, eg. this PHE data⦠2/
This is a follow-up to this older study in the same cohort. The older version of the study showed no increased risk of miscarriage following vaccination, but the follow-up time was shorter (10-12 weeks). 2/
Although the data from this study was reassuring, the limited follow-up time made it difficult to exactly calculate the miscarriage rate following vaccination, so an estimate was used.
After I wrote this thread about the potential effects of COVID vaccination in pregnancy and the lack of such effects in other vaccines, perinatal epidemilogist @deshaynef got in touch to tell me about some work she has done in this area... π§΅