Thread by @mega_pindang71

Potential Cause of COVID-19 ‘Long-haulers’ : antibodies specific for ACE2.

#ACE2
#LongCovid

"The antibody creates problems for the immune system by attacking the ACE2"

news.uams.edu/2021/09/09/uam…

"Patients with ACE2 antibodies have lower activity of soluble ACE2 in plasma. Plasma from these patients also inhibits exogenous ACE2 activity. ...

journals.plos.org/plosone/articl…

These findings are consistent with the hypothesis that ACE2 antibodies develop after SARS-CoV-2 infection and decrease ACE2 activity. This could lead to an increase in the abundance of Ang II, which

causes a proinflammatory state that triggers symptoms of PASC, Post-Acute Sequelae after SARS-CoV-2 infection."

ACE2 expression is dramatically reduced with aging in both genders: young-adult vs. old P < 0.001 (by 78% in male and 67% in female, respectively) and middle-aged vs. old P < 0.001 (by 71% in male rats and 59% in female rats, respectively).
pubmed.ncbi.nlm.nih.gov/16303146/

The decrease of ACE2 content was relatively slight between young-adult and middle-aged groups (by 25% in male and 18% in female, respectively). Although there was no gender-related difference of ACE2 in young-adult and middle-aged groups, a significantly higher ACE2 content was

detected in old female rats than male. In conclusion, the more elevated ACE2 in young adults as compared to aged groups may contribute to the predominance in SARS attacks in this age group.