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Viki Male Profile picture
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17 Nov, 7 tweets, 4 min read
"I'm #pregnant, and I've been offered a #CovidVaccine #booster. Should I accept?"

@RCObsGyn encourage all pregnant ppl in the UK to get their booster when they are offered it... 1/

rcog.org.uk/en/guidelines-… The JCVI advises that the booster vaccine dose should be off
If you are in the USA and pregnant or recently pregnant, you will be offered a booster vaccine as soon as you are six months out from dose 2. And @acog recommends you get it. 2/

acog.org/clinical/clini… Text from new ACOG guidance. ACOG recommends that pregnant a
But what's the evidence that #CovidVaccine #boosters are safe and effective in #pregnancy? 3/
Because boosters are pretty new, we don't yet have lots of data on the people who have received them during pregnancy.

So these recommendations are based on other sources of data... 4/
Dose 1 and 2 COVID vaccines have an excellent safety and efficacy record in pregnancy. There's way too much data on this to fit in a single tweet, but you can find everything you need to know here... 5/

drive.google.com/file/d/1_wHIYX…
We also know that, in non-pregnant people, boosters are similar to dose 1 and 2, in terms of safety. And they do boost protection. 6/

pfizer.com/news/press-rel…

nejm.org/doi/full/10.10…
Taking these two points together, we have every reason to believe that boosters will be safe and effective in pregnancy...

... just like dose 1 and dose in pregnancy.

... just like boosters in people who are not pregnant.

7/7

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More from @VikiLovesFACS

Viki Male Profile picture
17 Nov
How can we know that #COVID19 #vaccines will not harm #fertility? Could an effect unexpectedly appear years into the future?

👩🏻‍❤️‍👨🏾🤰🏻💉🤔

🧵...
Let’s start with the data we have on fertility right now.

👉🏻 No reduction in pregnancy rates in vaccinated (vs unvaccinated) ppl in clinical trials.

👉🏻 Egg quality, fertilisation rates and pregnancy rates are the same in vaccinated and unvaccinated IVF patients. 2/
👉🏻 No difference in sperm quality before vs after vaccination. 3/
Read 13 tweets
Viki Male Profile picture
15 Nov
Wondering if #COVID19 #vaccination affects #periods? 💉🩸🤔

So was I!

Preliminary results from my study on this are out today in preprint... 🧵

medrxiv.org/content/10.110…
To answer this question, we recruited two cohorts.

Cohort 1 consists of 250 people recruited before they received their COVID vaccine, who are keeping a record of their periods before and after vaccination. 2/
This cohort will give us an idea of how common it is to experience a menstrual change after COVID vaccination.

But many of them are still tracking their cycles, so we still have to wait for all the data to come in! 3/
Read 16 tweets
Viki Male Profile picture
3 Nov
A bunch of people have been in touch about this paper. Has a review of the evidence really raised questions about the safety of the Pfizer #COVID19 #vaccine in #pregnancy?

TLDR: No… 🧵
The paper purports to present a reanalysis of the V-safe pregnancy registry data to the end of February. You can find the original report (which concluded no increased risk of pregnancy complications following vaccination) here… 2/

nejm.org/doi/full/10.10…
But before we get into the details of what’s been done here…

There is no need to scry the six-month-old data from Shimabukuro! It was difficult to interpret because of the limited follow-up time, but *luckily* we now have longer follow-up data… 3/

nejm.org/doi/full/10.10…
Read 10 tweets
Viki Male Profile picture
21 Oct
Stressful times (war, famine) are associated with people experiencing more anovulatory and abnormal menstrual cycles.

But what about the pandemic? This paper used data from 18,076 ppl tracking their cycles with @NaturalCycles app to investigate… 🧵

journals.plos.org/plosone/articl…
The authors looked at user data entered from March - September 2019 (pre-pandemic) compared to March - September 2020 (Pandemic). They also asked users to rate their stress levels (retrospectively) in the pre-pandemic and pandemic periods. 2/
The average cycle length decreased from 29.4 to 29.q6 days, and the average period of menstruation increased from 4.21 to 4.23 days.

Neither of these changes is clinically significant. 3/
Read 13 tweets
Viki Male Profile picture
17 Oct
Are you #breastfeeding? Thinking about whether to get the #COVID19 #vaccine?

🤱🏾💉🤔

This is a thread for you!

🧵...
People who are breastfeeding can sometimes get forgotten in the focus on pregnancy. But your questions matter too! And I particularly want to make space to address those questions because a lot of people have contacted me, worried about one particular blog post... 2/
I'll get to that later. But let's start by saying that @RCObsGyn and @MidwivesRCM recommend the COVID vaccine if you are breastfeeding. 3/

rcog.org.uk/en/guidelines-…
Read 18 tweets
Viki Male Profile picture
14 Oct
Wondering if antibodies raised against #COVID19 #vaccines can bind to the placental protein syncytin-1 and harm #fertility?

💉👩🏽‍❤️‍👨🏻🤔

Out yesterday! More data that addresses this question!

Spoiler alert: they don’t... 🧵

nature.com/articles/s4142…
But why would anyone even think that such a thing might happen? Is it even worth researching?

The rumours that COVID19 vaccines would impact fertility were started by a vaccine skeptic who proposed that this might occur, so this is something that a lot of ppl may have heard. 2/
People who work in this area never thought this was very likely, for a number of reasons.

Not least, if this did happen COVID 🦠 would be associated with infertility or problems in early pregnancy, and luckily we don’t see that. 3/

Read 7 tweets

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