The posts from what we know in the last 3 days across the globe on #Omicron are all at one place here. Feel free to read along . The information from 29th November will follow in the thread below .Currently this is the known Geographic spread #RPSMTrust
Ctd2) All Variants of Concern have such clusters of sudden increase of mutations,the issue is they are coming up in an area where only 70% get access to Antiretroviral (HIV Tt) therapy,help needs to go a further step ahead - covid vaccines, antiretrovirals,logistics& Monoclonals
Ctd3) @michaelmina_lab tells us that the waste water surveillance is showing that the virus is spreading like crazy , that reminds me of what happened in Brazil after the P1 wave ended, they almost immediately had the P2 wave , this looks like a familiar story ctd)
Ctd4 Japan closes borders to all foreigners.
Ctd5)Marriage of the Two pictures one of the provinces and the second of the percentage people positive shows that while the positive population is highest in Gauteng BUT it is also rapidly growing in the southern states , north of Gauteng the growth is not as much @DrEricDing
Ctd7) @Antonio_Caramia made a good chart of cases & these have grown at astronomical rates, almost 6 times in last 2-3 weeks , we know that if cases rise hospitalizations & deaths rise in 4 to 6 weeks later .They will overwhelm hospitals .We know 18% infected need hospitals.
Ctd9) Yesteray We had updated that we expect that the RTPCR will work out fine ( if not better) and @michaelmina_lab had said he expected the Lateral Flow ( Rapid Tests ) would've been fine, here is more information that they are working
Ctd10) @davidrliu clearly shows the rate of change in spike protein and since Moderna /AZ /Pfizer all work at the spike protein there's fair chance that they MAY take a hit( so many mutations there).Oral medications like Paxlovid, Molnupiravir may not take that big a hit ctd)
@davidrliu Ctd11) Meanwhile Australia finds one more
@davidrliu Ctd12) #Omicron has been found in Europe ,Australia& North America ,Africans are wanting not be discriminated against, wishing the world community come together & stop global air travel for 3 weeks .WHO leaders @DrMikeRyan, @DrTedros ctd)
Ctd17)Community transmission found in Scotland. That shows the need to act fast, test & track immediately.
Ctd18)Now comes Portugal , Europe will soon find #Omicron all over if they don't act fast .
Ctd19) @hjelle_brian created a flutter when he noted that TMEM245 is a snatched human protein, @PeacockFlu ,@SGriffin_Lab ,@ChristosArgyrop . Months earlier I had read this . Is TMEM245 an alternative entry pathway #Omicron
piecehttps://www.eurekalert.org/news-releases/651439
Short🧵How #Covid is killing Health Care Workers ?? Today I met Mrs Tandon.Her husband a 52/M physician had #Covid during #Delta wave which had injured his lungs BUT he came back home & started his private practice.He remained fine till 10 days ago when he made a short trip ctd)
2/n He felt weak on returning & wanted rest .Next day he was feeling body ache , joint pain & slight fever.He tested & found his platelets ⬇️to 23,000 .Further testing showed Dengue-ve.He started feeling dyspnea & was shifted to hospital where his oxygen suddenly plunged.ctd)
3/n Testing Covid+ve,he was already in ICU when the results came & must have infected many.CT very bad.Was shifted on ventilation support but couldn't survive next 24 hrs.3rd case I have heard in last 48 hrs of ⬇️platelets,bodyache & sudden decompensation mimicking Dengue.ctd)
🧵 on why the past experiences aren't good enough #monkeypox disease was first confirmed in humans in 1970.When the outbreak happened most thought it will be a few cases based on earlier outbreaks BUT some of us believed otherwise. See the old tweet ctd)
2/n We were plain lucky to have the West African clade of #monkeypox spread and not the #Congo clade spread , had that happened those who are lecturing is would have been scurrying for cover. Whether it is #Nigeria or it is Globally #monkeypox has broken a lot of barriers.ctd)
3/n with massive undercounting globally we are at 70,000+ cases in 102 new countries.All with availability of #Vaccine & #Tecovirimat in many countries. It would have been thousands more - so even if anyone has experienced the past- it doesn't help - the field has changed ctd)
Short🧵 on the story of the swollen toe - A known of mine phoned 2 days ago, their 19 yr old daughter had suddenly developed a swelling in toe - 2 hrs earlier along with sore throat & slight fever. On my urging they did a rapid test-ve, the RT-PCR ordered for next day -ve ctd)
2/n The fever subsided with naproxen but thereafter neded paracetamol to keep it under check. The mother did not want further testing currently BUT the kid would be in isolation because they have a 90 yr old grandmother living with them .They will watch carefully &masked ctd)
3/n while I was reassuring the mother that it is okay to watch carefully and even though it is most probably #Covid toe , we just need to be very careful she said something and I quote " Dr I am fed up ,this girl is getting fever every 5 weeks ,nothing seems to help" ctd)
Short 🧵 On Persistence of #Ebola - Patient infective over 500 days & spreads infection by Sex- So with the risk of spill over we may see repeated outbreaks. In 2016, Guinea had recorded 3 probable, 7 confirmed cases, of which 6 were admitted at an Ebola treatment unit ctd)
2/n 4 patients died in the community ,4 patients in the ETU.Fatality ratio among probable & confirmed cases in this cluster in Guinea was 80% (8/10).They were closely related to viruses from the 2014–2016 outbreak, ruling out a new introduction from an animal reservoir ctd)
3/n Epi investigation revealed that case 1 had sexual intercourse with a male #Ebola survivor who reported sexual abstinence after discharge from Nov 2014 -August 2015 as recommended. From Sep 2015, he had occasional intercourse with various partners, including case 1 ctd)
Short 🧵 on why some people are showing resistance to acceptance of risk of #Covid. This is a thread not on those who have fallen to misinformation BUT on those who initially took good care, till the vaccines came through - Suddenly become extremely careless & don't mask ctd)
2/n When the pandemic started a physician with army background told me - You know when do maximum casualties take place usually and went to explain & I quote" the maximum casualties dont happen during the 1st 2-3 days when the armies face each other - both sides dig into - ctd
3/n their own bunkers or hide from shelling - The moment they find they are being targeted they jump from one place to another or scurry for cover.After 10 days weariness comes in & with it comes false sense of security or overconfidence in your gear - Ctd)
Short🧵Why I think #Covid can cause existential consequences for Human Race ?? For any species to continue it has to procreate,that depends on fertility of both men & women.We started getting edgy couple of months ago.Here's the original ctd
Ctd3) We know that the number of ova in a woman is fixed at birth.The body doesn't produce more ova.Only a fixed number mature rest die off , maturation needs hormones & lots of other factors. If either hormones or reservoir is reduced #risk ctd) my.clevelandclinic.org/health/article….