Preliminary report of #Omicron says Omicron is 1.3x more transmissible than Delta, & unvaccinated have 2.4x greater risk of severe. Those with BOOSTERS: 90% lower risk of severe outcome. But it’s only early ➡️main worry is if 2 doses enough—data is coming.
jpost.com/health-and-wel…
2) there are potentially data on Omicron and vaccines out there for 2 shots. But it hasn’t been shared yet… 👇 vote in the poll.
3) this 90% was just for 3 shots & severe. Things we still need to know:

📌Case mix of elderly / sick / immunocompromised?

📌3 dose efficacy for infection?

📌2 dose efficacy for hospitalization?

📌2 dose efficacy for infection?

📌2 dose efficacy by duration since 2nd shot?
4) Another model on #Omicron transmission speed by @JPWeiland estimates Omicron to be 4.5x higher than Delta. His model assumes no mitigation change prior to the #B11529 announcement, and the relative rise after Omicron emergence.
5) the doubling time of #COVID19 cases in SA is 3-4 days, says Dr @GosiaGasperoPhD — who accurately modeled Canadian transmission months ago.
6) And yes, hospitalizations are up in the Omicron epicenter area.
7) The SA National Institute for Communicable Diseases (@nicd_sa) says 87% of patients admitted to hospital in Tshwane are not vaccinated against Covid-19. The NICD says unvaccinated people are more likely to die from the disease. 

news24.com/news24/southaf…

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More from @DrEricDing

2 Dec
REINFECTION RISK—New #Omicron study finds huge surge in #COVID19 **reinfections**. Worse, relative to old waves—➡️ huge numbers of infections in new Omicron wave are reinfections. How much? 📍2.4x higher reinfection risk with Omicron. 🧵 HT @SACEMAdirector
medrxiv.org/content/10.110… Image
2) Not just merely a 2nd infection — is possible to also get a **THIRD INFECTION** with #COVID19. Let’s look at this graph - many people got a third infection recently too in the #omicron wave. 👇 Image
3) There has been 332 people in South Africa 🇿🇦 documented with a 3rd infection (aka a two reinfections). And 35k with one reinfection. Image
Read 6 tweets
2 Dec
BREAKING—New domestic-travel only #Omicron case identified in Minnesota of a travelers who visited New York City and attended an anime convention at the Javits Center Nov 19-21, and got symptoms on Nov 22nd. ➡️With such timeline, it could be now across US. content.govdelivery.com/accounts/MNMDH… Image
2) This one is more significant than the SF case yesterday because SF #Omicron had South Africa travel. This MN case had only domestic travel. And Nov 19-21 in NYC dates it before the variant was discovered and reported for the first time by South African authorities! 👀
3) Only a matter of time for more cases.
Read 6 tweets
2 Dec
(Whisper) ummm… a new subvariant of #Omicron has now been spotted with **P681R** spike mutation instead of P681H. The “681R” amino acid mutation is a key “bad” mutation that made Delta ⬆️more infectious. Most Omicron samples didn’t have it before➡️ now 1 has acquired it. 👀 ImageImage
3) another thread 🧵 on latest Omicron surge. See if you spot where Ghana 🇬🇭 enters the chat.
Read 6 tweets
2 Dec
FASTEST SURGE TO DATE—The #OmicronVarient is up swinging much faster in both new daily cases and positivity, than all previous waves in South Africa 🇿🇦, according to @nicd_sa data illustrated by @jburnmurdoch. This supports the faster transmission theory of #Omicron. 🧵 Image
2) and the upswing in South Africa is not just localized to one area. It’s seen across most provinces together. That a bad sign too.
3) a small early upswing of probable #Omicron is likely happening in England too.
Read 5 tweets
2 Dec
A rise in possible #Omicron in England—tripling (0.1 to 0.3) of S-Gene dropout PCR signal, which is a proxy for Omicron (before 🧬 sequencing confirms). @_nickdavies estimates this represents around ~60 cases in 🏴󠁧󠁢󠁥󠁮󠁧󠁿. Still early—but it displacing #DeltaVariant is not good sign. 🧵 Image
2) I again stress it’s early, but it’s a signal to watch. @_nickdavies notes these PCR signals all in the last 5 days.
3) to be clear, the “60” number is a excess number of SGTF beyond random lab error background levels.
Read 4 tweets
1 Dec
BREAKING—the @CDCgov has identified first case of the #Omicron variant in the US in California, via CNN source. #COVID19
2) we need initiate INTERNATIONAL arrivals testing + followup testing ASAP.
3) THIS. IS. DE. JA. VU. … feels like the the US is back in February 2020 all over again.
Read 9 tweets

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