Mia Malan Profile picture
Dec 4, 2021 11 tweets 8 min read Read on X
[Thread] JUST IN:
1. NEW #OmicronVariant data from the Steve Biko/Tshwane District Hospital Complex via @MRCza. Tshwane = where SA's Omicron outbreak started

1. Data = for the 1st 2 weeks of the outbreak (14-29 Nov)
2. Past 5 days (29 Nov-3 Dec) = exponential increase in cases
2.
1. 21% of #COVID19 patients = on oxygen because of COVID
2. This is lower than previous waves
3. 76% of patients = incidental COVID admissions (they were admitted 4 other conditions + found out they had COVID when they had to do a test)
Study: bit.ly/3Ig0753
3. What do we know about admitted patients' vaccination status?
Snapshot of 2 Dec:
Of 38 adults in #COVID19 wards:
* 6 = vaccinated
* 24 = unvaccinated
* 8 = unknown vaccination status

Of 9 patients with COVID pneumonia
* 8 = unvaccinated, 1 is a child
* 1 = vaccinated
4. Was the age profile of #COVID19 admitted patients different from other waves?

Yes. They were younger.

- 80% of admissions = people younger than 50 (this is also the case across Gauteng province, where Tshwane is located)
- 19% = children aged 0-9
- 28% = 30-39 years
5. Who died in hospital because of #COVID19?
There were 10 deaths between 14-29 Nov:
- 4 deaths = 26-36 years
- 5 deaths = 60+ years
- 1 death (child) = unrelated to COVID
- No #COVID deaths among 34 COVID admissions in the pediatric wards
6. What was the in-hospital death rate of #COVID19 patients?
- 6.6% (10/166 admissions died)

Is the death rate lower than the rate for previous waves? Yes. (Previous waves = 23%)

Does this mean that the #OmicronVariant causes fewer deaths? Not necessarily - we need more data
7. Why can't we assume this data shows fewer people die due to the #OmicronVariant (vs. previous variants)?

The data for this study = only for the 1st 2 wks of the outbreak. People take time to fall ill/die. It can take longer than 2 wks. Some patients may therefore still die.
8. How sick did admitted #COVID19 patients get?
1. 2 out of 166 admissions were in the #COVID ICU ward
2. 63 patients were in the high care ward (mostly not due to COVID), 3 had severe COVID pneumonia, which could mean that more patients are starting to get very sick
9. How long did #COVID19 patients stay in hospital for and is it different from previous waves?

Yes, it's different (much shorter). COVID patients stayed in hospital for an average of 2.8 days vs. the 8.5 days of previous waves. #OmicronVariant
10. Summary:
1. Most #COVID19 patients didn't know they had COVID when they got admitted (they were admitted for another condition)
2. A smaller % of patients required oxygen than in previous waves
3. Admitted patients were younger than in previous waves
4. We need more data
11. Want to read the full @MRCza study? Find it here: #OmicronVariant bit.ly/3Ig0753

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More from @miamalan

Jul 24
🧵1. BREAKING: The peer-reviewed results of the study of a 6-monthly jab, #lenacapavir, in which not a single of the 2134 women between 16-25 years who received the jab contracted #HIV, were released at #Aids2024.

Find the full study here:

bhekisisa.org/wp-content/upl…
Image
2. Women often find it hard to adhere to daily #oralPrEP. In the Purpose 1 trial, 91.5% of women returned on time for their next #lenacapavir jab at 26 weeks and 92.8% at week 52. Image
3. Only 4 women out of 2134 (0.2%) who received #lenacapavir dropped out of the trial because of injection-site reactions. Image
Read 15 tweets
Jan 17
[Thread] 12 things to know about the the proportion of pregnant women infected with #HIV from SA’s latest antenatal HIV survey. The survey is conducted by the @nicd_sa.

(Analysis of our 95-95-95 goals in my next thread later in Jan).

1/12 Image
2. What is the antenatal #HIV survey?

1. It measures the % of HIV+ pregnant women between the ages of 15 + 49.
2. Only women using state pregnancy clinics take part.
3. The survey has been conducted each year between 1990-2015, then in 2017, 2019 +2022. Image
3. How many pregnant women between 15-49’s blood was tested for #HIV? 37 828 out of 40 542 collected samples.
- 37 7171 = Black African women
- 37 541 didn’t live with the dad of their child
- 35,635 of dads were 5 years+ older than moms (this makes them more likely to get HIV) Image
Read 12 tweets
Jan 10, 2023
JUST IN [Thread]:
1.@healthza's Lesley Broomberg:
An extra #COVID19 booster jab for people of 18+ in SA will become available towards the end of JANUARY
- People of 50+ qualify for a 5th dose
- People of 18+ qualify for a 4th dose
2. Lesley Broomberg: Can you mix and match with additional boosters? Yes. You can choose whether you want a #JnJ or #Pfizer booster.
3. Lesley Broomberg:
Will teens of 12-17 qualify for boosters? Not at this stage. Why not? The #VMAC = not recommended booster doses for 12-17, based on an understanding that the protection provided by 2 #Pfizer doses = adequate, as 12-17 = @ low risk of severe #COVID19 illness
Read 5 tweets
Jan 10, 2023
[Thread] #JoePhaahla:
- Genomic surveillance Network reported the detection of the new subvariant XBB.1.5 in SA of a sample of a patient tested on 22 Dec
- Details of the patient = not known, it was a random sample taken for testing
- XBB.1.5 = also common in US
2. XBB.1.5 = common in US
#JoePhaahla:
- 97%+ of #COVID19 cases worldwide = still #Omicron
- XBB.1.5 cases = no major change in hospitalisations or deaths
- Immunity of SAs (vax and natural immunity) = still strong, so that is why we haven't seen much change in terms of hospital admissions/deaths
Read 5 tweets
Dec 13, 2022
🧵1. SA's @aspenpharma will be making 4 jabs (fill + finish) — pneumococcal, rotavirus, meningococcal, hexavalent — from 2023.

How will they finance this?
With a $30 million grant from @CEPIvaccines + @gatesfoundation.

Which APIs will Aspen use?
India's Serum Institute's
2. Why is it NB that an African company makes these jabs?

#Africa imports almost all its jabs. #COVID19 showed us this results in Africa being last in line to get vaccines during pandemics. The grant to Aspen is 1 of the 1st steps to change that.
3. What's the goal?

By 2040, the African Union wants #Africa to make 60% of the jabs the continent uses.

Why?
So that Africa is better equipped 2 respond 2 outbreaks (by developing the ability to make jabs + have technology in place to also make new jabs during pandemics).
Read 6 tweets
Dec 2, 2022
🧵1. BREAKING: @SAHPRA1 has confirmed the registration of the #HIV prevention jab, #CABLA in South Africa. On Thursday, #ViiVHealthcare issued their statement. ImageImage
2. Who can use the jab? @SAHPRA1 didn't specify restrictions for use in their statement, only that it is "a highly effective option for people at substantial risk of #HIV infection." Image
3. How does the jab work? It uses an #ARV called cabotegravir that prevents #HIV from replicating and entering someone’s cells. It’s taken every two months. Read my latest story for more. bit.ly/3ER7ejq
Read 5 tweets

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