If you get the #CovidVaccine while you are #pregnant, what cross the placenta? πŸ€”

This new preprint looked at 19 people vaccinated in pregnancy, and their babies, to find out... 🧡

medrxiv.org/content/10.110…
πŸ‘‰πŸ» Vaccine mRNA and Spike protein were not detectable in placenta or cord blood.

πŸ‘‰πŸ» Anti-spike IgM was not present in cord blood (which it would be if the babies had made their own response to the vaccine).

Two previous studies also found this... 2/

πŸ‘‰πŸ» We already know that anti-Spike IgG crosses the placenta, and might be expected to protect newborns against COVID. This study confirmed this.

This is in line with lots of previous work, which you can find under q8 of this document... 3/

drive.google.com/file/d/1_wHIYX…
πŸ‘‰πŸ» Babies followed up at 9-15 weeks still had anti-spike IgG.

This is expected, but still (to my knowledge!) the first study that has actually followed up babies to confirm this, so pretty cool! 4/
So what crosses the placenta when you get the #CovidVaccine in #pregnancy?

❎ Vaccine

βœ… Protective antibodies.

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More from @VikiLovesFACS

25 Nov
πŸ“’ The first large scale UK data on the safety of #CovidVaccine in #pregnancy is out today from @UKHSA !

In people giving birth between January and August, 24,759 of whom were vaccinated...

πŸ—οΈ No difference in stillbirth rate between vaccinated and unvaccinated... 1/
πŸ—οΈ No difference in babies with low birthweight between vaccinated and unvaccinated... 2/
πŸ—οΈ Preterm births occurred at a rate of 6.51% in vaccinated people and 5.99% in unvaccinated people.

This small difference is likely to be because at this time vaccinated people were more likely to be older and have underlying health conditions. 3/
Read 6 tweets
19 Nov
When is the best time in #pregnancy to get the #CovidVaccine?

πŸ€°πŸΎπŸ’‰πŸ€”

Two studies came out this week that tackle the question. And (bonus!) which vaccine to go for...

🧡...
But first! I should say that all the *safety* data says that it's equally safe to get the vaccine in any trimester.

So the question here is really when it's most *protective* to get the vaccine.

Links to safety data here... 2/

drive.google.com/file/d/1_wHIYX…
The first study, from @EdlowLab, looked at 158 people vaccinated in pregnancy, broken down by vaccine type and trimester of vaccination. 3/

medrxiv.org/content/10.110…
Read 15 tweets
17 Nov
How can we know that #COVID19 #vaccines will not harm #fertility? Could an effect unexpectedly appear years into the future?

πŸ‘©πŸ»β€β€οΈβ€πŸ‘¨πŸΎπŸ€°πŸ»πŸ’‰πŸ€”

🧡...
Let’s start with the data we have on fertility right now.

πŸ‘‰πŸ» No reduction in pregnancy rates in vaccinated (vs unvaccinated) ppl in clinical trials.

πŸ‘‰πŸ» Egg quality, fertilisation rates and pregnancy rates are the same in vaccinated and unvaccinated IVF patients. 2/
πŸ‘‰πŸ» No difference in sperm quality before vs after vaccination. 3/
Read 13 tweets
17 Nov
"I'm #pregnant, and I've been offered a #CovidVaccine #booster. Should I accept?"

@RCObsGyn encourage all pregnant ppl in the UK to get their booster when they are offered it... 1/

rcog.org.uk/en/guidelines-… The JCVI advises that the booster vaccine dose should be off
If you are in the USA and pregnant or recently pregnant, you will be offered a booster vaccine as soon as you are six months out from dose 2. And @acog recommends you get it. 2/

acog.org/clinical/clini… Text from new ACOG guidance. ACOG recommends that pregnant a
But what's the evidence that #CovidVaccine #boosters are safe and effective in #pregnancy? 3/
Read 7 tweets
15 Nov
Wondering if #COVID19 #vaccination affects #periods? πŸ’‰πŸ©ΈπŸ€”

So was I!

Preliminary results from my study on this are out today in preprint... 🧡

medrxiv.org/content/10.110…
To answer this question, we recruited two cohorts.

Cohort 1 consists of 250 people recruited before they received their COVID vaccine, who are keeping a record of their periods before and after vaccination. 2/
This cohort will give us an idea of how common it is to experience a menstrual change after COVID vaccination.

But many of them are still tracking their cycles, so we still have to wait for all the data to come in! 3/
Read 16 tweets
3 Nov
A bunch of people have been in touch about this paper. Has a review of the evidence really raised questions about the safety of the Pfizer #COVID19 #vaccine in #pregnancy?

TLDR: No… 🧡
The paper purports to present a reanalysis of the V-safe pregnancy registry data to the end of February. You can find the original report (which concluded no increased risk of pregnancy complications following vaccination) here… 2/

nejm.org/doi/full/10.10…
But before we get into the details of what’s been done here…

There is no need to scry the six-month-old data from Shimabukuro! It was difficult to interpret because of the limited follow-up time, but *luckily* we now have longer follow-up data… 3/

nejm.org/doi/full/10.10…
Read 10 tweets

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