We need to always keep in mind #Omicron's potential to lead to #LongCovid
Many early omicron symptoms have been described as "mild" in the press. Yet, they are potentially signs of growing, severe, prolonged pathology, like neurological impairment and immune dysfunction
We always need to remember covid often starts with a milder prodromal phase (early few days). More severe pathology can develop across the disease course, especially in view of immune dysfunction, neurological impairment and vascular damage --->
#LongCovid
Earlier variants appear to have been more likely to lead to severe pulmonary pathology, with a first peak in the second week --- often dubbed "second week crash". This can also be accompanied by life threatening "silent hypoxia" | barely symptomatic low saturation

#LongCovid
Earlier reports and animal models *seem* to indicate less severe lung pathology *on average* than with other variants--- especially in the vaccinated. Pneumonia and life threatening pathology in early #Omicron however do remain a real threat

#LongCovid
Emerging evidence including from the #LongCovid community reporting on reinfection--- and early healthcare data --- do suggest #Omicron may lead to prolonged symptoms and sequelae. We know that omicron that can kill and bring people to the hospital
We don't know the full range of action of this variant, especially in those who aren't full vaccinated. These include little children. We need to remain vigilant and avoid premature minimizing of the dangers from #Omicron

#LongCovid

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More from @elisaperego78

12 Jan
Letting #Omicron rip is wrong

It remains a SARS virus. It is able to kill and send people to hospital. We know omicron is able to infect with symptomatic, sometimes severe disease even the vaccinated, or those with previous infection. This is *bad*

🧵
People who already have #LongCovid, had previous covid but recovered, or still have covid-related subclinical (barely symptomatic damage) could be particularly at risk from a variant which is so good at reinfection.

Are multiple SARS-CoV-2 infections good? I wouldn't bet on it!
Not everyone in the world is vaccinated, or boosted, especially children --- do we *really* want a SARS virus to infect kids unchecked?! People in low-income countries, or marginalised communities, don't have access to vaccination. Not everyone responds optimally to vaccination
Read 8 tweets
11 Jan
Bad opinion piece in @guardian trying to prime people, in my opinion, to accept mass infection | death | #LongCovid
The overall argument is that in view of "naive" [sic] zero covid policy, Australians are now having "anxiety" to accept infection

🧵
theguardian.com/australia-news…
To be absolutely clear: • mass infection with a SARS virus is a deranged, dangerous policy that will result in lasting health problems in many of those infected. Being worried about mass infection with SARS-CoV-2 is absolutely right

#LongCovid
• a poorly controlled SARS-CoV-2 spread will bring about social, economic, healthcare and personal disruption. The amount and gravity of this will depend on how the spread will be managed. But it is absolutely appropriate to be concerned and worried about it

#LongCovid
Read 7 tweets
10 Jan
This is a scary, concerning, but excellent point we all have to reflect upon --- especially as patients and researchers. We've seen a large amount of erroneous, incorrect views about SARS-CoV-2 coming from public health experts and those in healthcare

#LongCovid

🧵
These erroneous ideas included comparing covid --- a SARS like disease --- to a "flu" or a "cold" | denial about #LongCovid and the effects of SARS-CoV-2 infection on pediatric patients ----> #LongCovidKids, MIS-C etc. | Denial of airborne transmission #COVIDisAirborne
Promotion of herd immunity and mass infection theories | Great Barrington Declaration | #MildCovid | denial of the multi-system nature of covid, including its vascular, neurological and clotting components | "endemic covid" = mild
Read 5 tweets
9 Jan
Not a positive take, I am afraid, from the @guardian about "endemic covid" and "mild" #Omicron
I don't like calling a "ray of light" a SARS-CoV-2 variant which is spreading at the speed of light, is putting children in hospital, and is killing

🧵

theguardian.com/world/2022/jan…
It is possible that #Omicron is "milder" on average in the acute pulmonary phase --I say milder, not "mild" --than other variants of concern. But we still don't know in detail about the full spectrum of disease that this VOC can cause in the long-term, especially in #LongCovid
We don't know which long-term trajectory of development this virus will take in months or years. We don't know if #Omicron or other evolving SARS-CoV-2 strains will give rise to new, more dangerous variants. We already know omicron is killing and putting people in hospital
Read 6 tweets
6 Jan
#LongCovid was defined by the patient-advocate-researchers who first identified | named the condition as a prolonged form of severe covid, indeed 🔥
This is in the 2020 peer-reviewed | medical literature
Policy makers are trying to minimize it to promote erroneous policy

🧵
For example, prominent #LongCovid researcher Prof. @felicitycallard successfully and powerfully questioned the "mild covid" narrative in a May 2020 academic publication

#MildCovid

somatosphere.net/2020/mild-covi…
In "How and Why Patients Made Long Covid" @felicitycallard and I make clear many early #LongCovid advocates | patient researchers had severe, life threatening covid

Many were left at home with no care in extreme conditions. These are real people

sciencedirect.com/science/articl…
Read 12 tweets
5 Jan
I recommend reading this great thread about the long-lasting effects of SARS-CoV-2 infection
Again, this isn't news. We patient-researchers in the first wave had correctly, scientifically, defined covid as a multi-system and prolonged disease ---> #LongCovid

🧵
The narrative that covid was a respiratory disease, mild and short in the young, was wrong. It was blown away by patients in the early 2020, including in academic peer-reviewed pieces

The rise of #LongCovid is narrated in my paper with @felicitycallard

sciencedirect.com/science/articl…
I also suggest to read this great piece by physician-researcher @zalaly in the @guardian on the critical impact of #LongCovid patient-led advocacy and research in medicine

amp.theguardian.com/commentisfree/…
Read 6 tweets

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