Thread by @VikiLovesFACS

*New data* from 79,148 ppl giving birth in Scotland Mar 20 - Oct 21.

🦠 #COVID ⬆️ risk of stillbirth or neonatal death by ~4x, and preterm birth by ~2x

💉 #CovidVaccination protects against COVID and is not associated with poor #pregnancy outcomes. 1/

nature.com/articles/s4159…

This gives us some homegrown data on vaccine effectiveness in pregnancy, including in the delta wave. Roughly speaking, vaccination reduces the risk of...

Any infection by 30%

Hospitalisation by 72%

ICU by 94%

2/

The findings are roughly in line with what we already know about the outcomes of COVID in pregnancy.

We usually say that stillbirth is 3x more likely following infection. The slightly higher number here may be because they also counted babies dying shortly after birth... 3/

... or because we have (sadly) seen the rates of these outcomes increasing in the delta wave, and this study covers more of the delta wave than previous studies did... 4/

...or because this is whole population data, and does not account for the fact that certain groups of people are more likely to suffer from both COVID infection and poor obstetric outcomes. 5/

The data on #CovidVaccine safety in #pregnancy is absolutely in line with lots of studies we already have - but it's always good to have more reassuring data! 6/

drive.google.com/file/d/1_wHIYX…

The data on vaccine effectiveness against all infection is a little bit lower than we have seen in earlier studies. This may be to do with alpha versus delta waves, or waning immunity. 7/

nature.com/articles/s4159…

jamanetwork.com/journals/jama/…

But protection against hospitalisation or ICU remains high - as in previous studies.

This underlines the importance of getting your #CovidVaccine if you are #pregnant. 8/8