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Viki Male Profile picture
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Jan 20 • 6 tweets • 4 min read
2,126 couples #TryingToConceive between Dec 2020 and Sep 2021…

👩‍❤️‍👨💉 #CovidVaccination made no difference to per cycle chance of #pregnancy

👩🏻🦠 Infection of female partners made no difference…

👦🏽🦠… but in males ⬇️ chance of pregnancy for ~60d.

academic.oup.com/aje/advance-ar…
The finding that #CovidVaccination does not affect #fertility mirrors what we have already seen in IVF settings, but it is good (if unsurprising!) to see it confirmed among those #TryingToConceive the old fashioned way! 2/

drive.google.com/file/d/1_wHIYX…
This is the first study to look at the effects of #Covid infection on #fertility.

It’s reassuring to see that it doesn’t affect chance of conception in female partners. 3/
The finding that chance of conception is temporarily reduced when the male partner catches Covid is expected, given that we know Covid infection temporarily harms sperm count and quality. 4/

sciencedirect.com/science/articl…
But it is important to be clear that this effect is short-lived!

However, this does provide added impetus to those TTC to get vaccinated.

👦🏽 Prevents COVID-related fertility reduction

👩🏻 Protection in advance of pregnancy

5/
Congrats to @AKWesselink and the @BUPRESTOStudy in this nice piece of work!

6/6

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More from @VikiLovesFACS

Viki Male Profile picture
Jan 13
*New data* from 79,148 ppl giving birth in Scotland Mar 20 - Oct 21.

🦠 #COVID ⬆️ risk of stillbirth or neonatal death by ~4x, and preterm birth by ~2x

💉 #CovidVaccination protects against COVID and is not associated with poor #pregnancy outcomes. 1/

nature.com/articles/s4159…
This gives us some homegrown data on vaccine effectiveness in pregnancy, including in the delta wave. Roughly speaking, vaccination reduces the risk of...

Any infection by 30%

Hospitalisation by 72%

ICU by 94%

2/
The findings are roughly in line with what we already know about the outcomes of COVID in pregnancy.

We usually say that stillbirth is 3x more likely following infection. The slightly higher number here may be because they also counted babies dying shortly after birth... 3/
Read 8 tweets
Viki Male Profile picture
Jan 7
Does #CovidVaccination cause changes to #periods?

I know ppl have been wondering about this! But up to now the data we had was pretty preliminary. However, with a large, prospectively collected dataset out yesterday, I think it’s time to start putting it all together.... 🧵
Here’s some more on that new study. In short, people who received both doses of the vaccine in a single menstrual cycle found their period came a couple of days late. But it was back to normal a couple of cycles later, so the change was temporary. 2/

This might explain why our UK-based study couldn’t find clear patterns to suggest that Covid vaccination is associated with changes to periods. In the UK, our interdose interval is 8 weeks, so it’s not possible to have both doses in the same cycle. 3/

Read 18 tweets
Viki Male Profile picture
Jan 6
Does #CovidVaccination cause changes to #periods? Biggest and best study so far...

In summary: on average, periods are delayed by ~half day by dose 2 of the vaccine, and delayed by ~2 days if you get both doses in the same cycle. But it's temporary! 🧵

journals.lww.com/greenjournal/F…
3959 spontaneously cycling ppl logged at least 6 consecutive cycles with tracking app @NaturalCycles.

2403 were vaccinated. Taking them all together, the average period came 0.64d late after dose 1 and 0.79d late after dose 2. No difference in length of period. 2/
Most of us wouldn’t even notice this! But could the average be hiding some small fraction of people who experience a large change? We define any variation in cycle length of less than 8 days as “normal”. 3/

obgyn.onlinelibrary.wiley.com/doi/10.1002/ij…
Read 13 tweets
Viki Male Profile picture
Dec 16, 2021
If you get the #CovidVaccine while you are #pregnant, what cross the placenta? 🤔

This new preprint looked at 19 people vaccinated in pregnancy, and their babies, to find out... 🧵

medrxiv.org/content/10.110…
👉🏻 Vaccine mRNA and Spike protein were not detectable in placenta or cord blood.

👉🏻 Anti-spike IgM was not present in cord blood (which it would be if the babies had made their own response to the vaccine).

Two previous studies also found this... 2/

👉🏻 We already know that anti-Spike IgG crosses the placenta, and might be expected to protect newborns against COVID. This study confirmed this.

This is in line with lots of previous work, which you can find under q8 of this document... 3/

drive.google.com/file/d/1_wHIYX…
Read 5 tweets
Viki Male Profile picture
Nov 25, 2021
📢 The first large scale UK data on the safety of #CovidVaccine in #pregnancy is out today from @UKHSA !

In people giving birth between January and August, 24,759 of whom were vaccinated...

🗝️ No difference in stillbirth rate between vaccinated and unvaccinated... 1/
🗝️ No difference in babies with low birthweight between vaccinated and unvaccinated... 2/
🗝️ Preterm births occurred at a rate of 6.51% in vaccinated people and 5.99% in unvaccinated people.

This small difference is likely to be because at this time vaccinated people were more likely to be older and have underlying health conditions. 3/
Read 6 tweets
Viki Male Profile picture
Nov 19, 2021
When is the best time in #pregnancy to get the #CovidVaccine?

🤰🏾💉🤔

Two studies came out this week that tackle the question. And (bonus!) which vaccine to go for...

🧵...
But first! I should say that all the *safety* data says that it's equally safe to get the vaccine in any trimester.

So the question here is really when it's most *protective* to get the vaccine.

Links to safety data here... 2/

drive.google.com/file/d/1_wHIYX…
The first study, from @EdlowLab, looked at 158 people vaccinated in pregnancy, broken down by vaccine type and trimester of vaccination. 3/

medrxiv.org/content/10.110…
Read 15 tweets

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