Interesting study on #LDL #cholesterol via #SoybeanOil.

- Uses LDLr “knock out” mice, thus poor clearance

- Yet lower #LDL observed anyway

- Differences for “conventional” vs “modified” oils

- Conventional same plaque levels as SFA control

Ht @KCKlatt irp.nih.gov/blog/post/2022…
“After 12 weeks, the mice fed conventional soybean oil had much lower levels of VLDL and LDL cholesterol… compared to the mice fed lots of saturated fat. However, to the researchers’ surprise, the mice on those two diets had the same amount of plaque buildup in their arteries…”
Naturally, I’m especially interested in how much impact this diet had on resulting oxidative potential of newly synthesized lipoproteins and how much (or how little) of these reduced Lp-X levels could be a result of scavenger receptor removal in particular.

cc @TuckerGoodrich

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Dave Feldman

Dave Feldman Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @realDaveFeldman

Nov 8
1/ Respectful rebuttal 🧵:

I think you make valid points with regard to a diet community having bad actors that can reflect on it, @jerryteixeira -- but I'd push back that one has to tow the party line on high fat and/or high meat in #keto or get hammered.

Some examples...
2/ I myself have brought up #PlantBasedKeto many times over to raise awareness, even though I try to avoid the diet debates. But I've not suffered any repercussions from the keto community.

3/ DietDoctor.com is arguably the largest resource for #LowCarb diet, and in the last couple years have put out a great deal more material on higher protein with lower fat as a diet direction option. Many low carbers prefer this emphasis over higher fat as a %
Read 5 tweets
Nov 8
🚨New #LMHR Editorial in JCL!🚨

🙏Please RT🙏

- Cautious consideration for #LMHRs
- Calls for patient-centered approach
- Calls for more research on #LMHRs(!)

AND we raised money from the LMHR community to make this *open access*.

Let's unpack... /1 authors.elsevier.com/a/1g22A6tb2E2O…
2/ So why is this a big deal?

Two reasons:

For one, this editorial is the first of its kind to gather MDs and PhDs together to help develop a clinical position on the #LMHR phenotype and importance of expanding research around this phenomenon.

That's hard to understate!
3/ Typically, there have been just two positions on the topic of high LDL on keto, particularly LMHRs.

- Conventional: LMHR *must* lower LDL/ApoB

- LH skeptic: LMHR can ignore LDL/ApoB

This editorial concludes those with high LDL-c/ApoB from keto "should consider" lowering.
Read 10 tweets
Nov 1
🙌 Okay, it's Nov 1 -- I'm back! 🙌

A catch up 🧵

✅ Social Media Hiatus was nice (I recommend)

#LMHRstudy near recruitment goal

✅ 3 new research endeavors in works!

✅ Possible film project next year

Read on for the unpacking... /1
2/ The Social Media Hiatus...

I was originally shooting for a few weeks away, but it stretched into two months.

Honestly, I have to really credit @MichaelMindrum for inspiring me to really commit to this. It was easier than I assumed given the ongoing research efforts. Image
3/ The #LMHRstudy is nearing recruitment completion!

That said - we still have some participants to go to put us over the top!

So again, *please* visit LMHRstudy.com to see if you or someone you know is eligible for the study.
Read 5 tweets
Aug 28
1/ Two things..🧵

1️⃣ We need to complete registration!

You / someone you know:
👉Had LDL 160 or under before keto
👉LDL increased to 190 or more on keto
👉HDL 60 or more
👉Triglycerides 80 or below
👉2 or more years on keto

Go to LMHRstudy.com & see if u/they qualify
2/ Participants get:

🧬 Genetic testing

🩸Wide spectrum bloodwork

🫀 Advanced #CCTA scans

🚨🚨🚨YOU can help us get our target of 100 participants. Please do!

👉👉👉LMHRstudy.com
3/ Please consider:

✅ Retweeting this tweet thread

✅ Sharing this thread or its contents in #Keto and #Carnivore #Facebook groups

✅ Sharing on #Instagram

✅ ... and, of course, you may already know people personally who fit this profile -- please reach out to them!
Read 5 tweets
Aug 19
1/4 Curiosity thread 🧵
(with a poll)

While much of the feedback on @nicknorwitz’s new paper (below) has been positive, there have been some with concerns regarding use of CGMs for @harvardmed students in this context.

So I want to ask a couple questions…
2/4 Assume the entire experiment was performed in an identical manner save one change:

Instead of using CGMs, the students simply did a high frequency of finger stick blood tests through a glucose monitor (glucometer), effectively getting likewise results to those reported.
3/4 Would this one alteration alleviate much of the concern about the CGM use?
Read 4 tweets
Aug 2
Four part true/false #poll, with an open question at the end…

1/ True or False

If someone said they get 35% or less of their fat calories from saturated fat, you would consider them on a “low saturated fat diet”
2/ True or False

If someone said they get 10% or less of their fat calories from saturated fat, you would consider them on a “low saturated fat diet”
3/ True or False

If someone said they get 35% or less of their total calories from carbohydrates, you would consider them on a “low carb diet”
Read 5 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(