The Unique Regulation of Glucose and Ketosis in the Brain 🧵(1/4)
Regulatory controls are tighter in the brain than in the periphery. Glucose and glycogen regulation happens in the glia in the brain. #glia (2/4)
Ketosis can take 24-36 hours to achieve in the periphery, but the brain goes into ketosis every night. Glial glycogen stores are depleted within 6-8 hours. #ketones (3/4)
I don't know who needs to hear this but ketones are an important part of homeostatic regulation. You might be afraid of ketones. But your brain relies on them. (4/4) #ketogenic#brainhealthmatters#metabolicpsychiatry
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A KD, or ketogenic diet, may be able to mimic the effects of mood stabilizers, which are commonly prescribed to treat bipolar disorder #BD. 🧵(1/5)
There are three main categories of mood stabilizers: lithium salts, anticonvulsants, and antipsychotics. However, the effectiveness of these medications can vary depending on the type of Bipolar disorder, and their exact mechanisms of action are not fully understood. (2/5)
Unfortunately, long-term use of pharmaceuticals can lead to negative side effects, such as chronic cardiovascular and metabolic issues. (3/5)
Psychiatric disorders often have a dynamic trajectory, with a "precipitating stressor" causing an initial destabilization that leads to a "first break" or onset of the disorder. (1/4) #mentalillness#mentalhealthmatters
Even after periods of remission, another stressor can cause a relapse, and many psychiatric disorders have a periodic element. (2/4) #neurology#metabolicpsychiatry
This means considering the initial stressor and how it interacts with an individual's susceptibility and other factors over time. (3/4)
A well-formulated ketogenic diet for brain health excludes grains. Let me tell you why. (1/7) #ketogenic
The effect of glutens aside, you want the full benefit of your nutrient-rich diet. You don't want to eat things that bind to the minerals you eat and make them inaccessible for your use. Like, you can do that, but what's the point? (2/7) #nutrition
Your brain needs minerals for optimal functioning. It's all about the mitochondria. And they need those minerals. Check out these key points from this important paper 👇(3/7) sciencedirect.com/science/articl…
Addressing dysfunctional brain metabolism and finding brain health comes not just from changing your fuel source but also from adequate micronutrient intake. Your brain relies on these to make energy and they play an important role in health brain metabolism. 🧵(1/8)
With different environmental (chemicals, pathogens, viruses), emotional, and highly processed food stressors, we are using up a lot more micronutrients than we think. (3/8)
Is the field of Metabolic Psychiatry new and emerging? Actually no. There has been a long history of metabolism being known to play a role in mental illness. #metabolicpsychiatry#mentalillness (1/12)
@ChrisPalmerMD provides an excellent outline of what we knew and when in this talk on the @Metabolic_Mind YouTube Channel (2/12)
Brain Fog comes before the criteria are met for Mild Cognitive Impairment (MCI). What are the symptoms of MCI? You might recognize them as what you are currently dealing with in your own recurrent or chronic brain fog symptoms. #brainfog#mci#mood 🧵(1/14)
You forget things more often.
You miss appointments or social events.
You lose your train of thought. Or you can't follow the plot of a book or movie. #brainfog#mci#mood (2/14)
You have trouble following a conversation.
You find it hard to make decisions, finish a task or follow instructions.
You start to have trouble finding your way around places you know well. (3/14) #brainfog#mci#mood