HOM3OSTASIS.com/Protocol Profile picture
Feb 24, 2023 52 tweets 40 min read Read on X
3VOLUTION of Homo sapien to HOM3OSTASIEN​

by Dmitry Kats, PhD, MPH

- - -

A HOM3OSTASIEN represents the evolutionary step forward undertaken by the homo sapien species (among other mammals) to substantially extend and reestablish healthy, fulfilling,… twitter.com/i/web/status/1…
... "inhibition of nuclear de novo NAD+ synthesis reduced the total levels of NAD+ in the cell and mitochondrial energy metabolism, leading to premature cellular senescence"

"nuclear de novo NAD+ synthesis pathway, controlled by H2AX [i.e., GPR109A aka HOM3OSTASIS.com/2022/11/homo-s…twitter.com/i/web/status/1… ImageImageImageImage
... Little do people know, as they don’t care to review the actual literature, that per se, akin to every other cell in the body, as proved in these high-profile journal-published papers (collecting Internet-dust) by the world's most elite investigators (scientists and/or… twitter.com/i/web/status/1… Image
... For more of such research + clinical literature, please visit t.me/STUDI3S and dig through our dynamically updated digital library:

.... To browse just a small sample of thousands saved from the perhaps now millions of reports, really documented trajectory observations from population-representative samples spanning more than 44 nations across the globe, please check out:


... HOM3OSTASIS.com/memberships

Support the truth by donating to our 501(c)(3) registered nonprofit charitable organization by signing up to #FeelTheHeal yourself … no commitment/money back literally thermodynamically-given guarantee … you want to be guided though and immersed …… twitter.com/i/web/status/1… Image
^ 🐝 With that...

Next week’s HOM3OSTASIS.com lineup:

- Live Q&A Monday Feb 27th at 5:30pm

- PodKats Wednesday March 1st at 7:00pm

- Newcomers Club Friday March 3rd at 6:00pm

All times* are EST USA

*If there is a time you would like that works better for you, please… twitter.com/i/web/status/1… Image
^I wrote all this freehand… I don’t waste time trying to sound smart on social media (I save that for my manuscripts, nowadays all made sure to be censored from publication into even the preprints, because you know why).

The truth I share talks, and I…
^ Ain't that right, @therealjuicy?

Can't wait for you to join us so I can peep you on game (and soooo sooooo many other individuals and populations) during our next #PodKats (March Wednesday March 1st at 7pm EST USA) about this:

^ … sigh.. I think you see what I mean 👇🏻

Peace ✌️
^ Before it's too late...

"Cells were challenged with 1 μm ionomycin to test their viability at the end of recordings. ATP, ivermectin, and ionomycin were applied by superfusion"
Mechanism of Ivermectin Facilitation of Human P2X4 Receptor Channels
rupress.org/jgp/article/12…twitter.com/i/web/status/1… ImageImageImageImage
^ How could I have forgotten the “Big C” … as in super-accelerated cellular senescence along the Warburg Effect, i.e., flush niacin (Re: Warburg) + glutamine deficiency that remains not eradicated and only skyrocketing across the globe in incidence, colloquially termed cancer?… twitter.com/i/web/status/1… ImageImageImageImage
^… 👀👀👀👀👀
"Niacin was the top-ranked micronutrient in reducing triglyceride levels and increasing high-density lipoprotein cholesterol levels"

"For TG and LDL cholesterol reductions, Niacin was the top-ranked effective micronutrient for reducing TG levels. Niacin can… twitter.com/i/web/status/1…
… “Other viral infections, for example, with murine coronavirus, upregulate the expression of pro-viral PARP enzymes within their cytokine response [101]. More recently, the disproportionately more frequent adverse outcomes due to COVID-19 infections in mdpi.com/2073-4409/12/3…twitter.com/i/web/status/1…
^ ... A Spoonful Of Sugar - Julie Andrews in Mary Poppins 1964

^ "Glutamine is a major dietary amino acid that is both a fuel and nitrogen donor for healing tissues damaged by chemotherapy and radiation. Evidence supports the benefit of oral (enteral) glutamine to reduce symptoms and improve and/or maintain quality of mdpi.com/2072-6643/12/6…twitter.com/i/web/status/1…
^ "We found a significant reduction in glycaemic and insulin responses when sugar replaced the rapidly digested starch in a processed breakfast cereal, i.e. the opposite of what is commonly believed. Thus sweetened breakfast cereals may not compromise pubmed.ncbi.nlm.nih.gov/7835329/twitter.com/i/web/status/1…

A teaspoon of sugar and a pinch of salt: Reviewing hyperosmolar therapy

^For those w/diabetes, no worry:

@US_FDA has approved, even recommends niacin (as monotherapy but powered w/equimolar glutamine & glucose=half of table sugar) for especially those w/T2D:

“niacin can be safely and should be used in patients w/diabetes"
^+ Just as w/disease-driving NAD-precursors (nicotinamide, NR, NMN) & irrelevant rodent research, do NOT confuse flush niacin (immediate release nicotinic acid) w/other call 'em "fake niacins"--biopharma-altered (sustained or extended) release "niacin"!
^ Looks like the sugar (if pure table sugar aka sucrose, which is one mole glucose + one mole (irrelevant but probably will even help a little in citric acid cycle) fructose) mass ratio calculation, incorporating niacin and glutamine, comes out to..

For HOM3OSTASIS.com/Protocoltwitter.com/i/web/status/1…
^ Meanwhile, here’s ivermectin lmfaoooo … “extremely safe and effective”, right? People aren’t being seriously harmed and murdered across the globe by this most toxic pesticide ever!

Adverse drug reactions associated with ivermectin use for COVID-19 reported in the World Health… twitter.com/i/web/status/1… ImageImageImageImage
^ Again, “extremely safe and effective”, right?

👇🏿 ImageImageImageImage
^ “Extra sugar and early induction promote peptide production yield
The optimization for circularin A production mainly focused on the modifications of the growth medium, and the effect of each examined parameter was investigated independently. Compared frontiersin.org/articles/10.33…twitter.com/i/web/status/1…
... When Krehl was chair of Biochemistry at @Yale in 1958:
Effect of Dietary Fats on Glucose Tolerance & Alloxan Diabetes

Speaking of which, remember when Bollet was @YaleMed's chair in 1992 & published this:

Politics and Pellagra
^Remember incoming to our era's global niacin (catalyzed & synergised by equimolar glutamine & glucose) deficiency—#COVID19—the causally inferring Bayesian MCMC models of my dissertation for epidemiology PhD at @UNCpublichealth converged, unearthing niacin
... Концепция «Быстрая Метаболическая Оптимизация»
при предоперационной подготовке пациентов в абдоминальной хирургии
The Metabolic Optimized Fast Track Concept: preoperative preparation for abdominal surgery

"In recent years the protocols of Enhanced… twitter.com/i/web/status/1… ImageImageImageImage
#Niacin #Tinnitus #Glutamine #Glucose

"We identified negative correlations between blood concentrations of NA [nicotinic acid] to NAD+ and hearing ability at 1000 & 2000 Hz, metabolic pathway associated with ARHL onset or progression"

... MORE JUST PUBLISHED #Niacin #Diabetes
“Our study aimed to explore the association between dietary niacin intake and risk of diabetes in the adult population in the United States.

Conclusions: Our results suggest that consumption of adequate amounts of niacin can reduce the… twitter.com/i/web/status/1…
... AND MORE JUST PUBLISHED #Niacin #Pregnancy #Natal #Health #Development #Pediatrics #Moms #Babies HOM3OSTASIS.com
“Pending a consensus on a safe niacin dose for pregnancy, the advice by Palawaththa et al. [1]: suggesting niacin supplementation to women of reproductive… twitter.com/i/web/status/1…
^ To preserve, restore, &/or enhance also #Fertility #Reproduction, adequate amounts of equimolar #Niacin + #Glutamine—w/synergy from equimolar #Glucose (all dissolved in clean, ideally distilled (from amber glass container), <room temp. water)—must be supplemented. Sufficiently… twitter.com/i/web/status/1… ImageImageImageImage
^ Completely forgot about this, speaking of #Tinnitus:

“negative correlations between blood concentrations of nicotinic acid & hearing ability at 1000 & 2000 Hz. NAD+ metabolic pathway associated with ARHL onset or progression”

^ #HOM3OSTASIS #Niacin #Glutamine #INFINITY

"late-life restoration of NAD+ levels rescues female reproductive function in mammals”

NAD+ Repletion Rescues Female Fertility during Reproductive Aging

^ And for the fellas:
“We therefore developed a… twitter.com/i/web/status/1…
^ Oh, I forgot about this for the ladies too per the above content...

^”One believes things because one has been conditioned to believe them”

“Most men & women will grow up to ❤️ their servitude and will never dream of revolution”

“Great is truth, but still greater, from a practical point of view, is silence about truth”

psychotherapy.net/blog/title/alc… ImageImageImageImage
^ “The saddest aspect of life right now is that science gathers knowledge faster than society gathers wisdom.”
~ Isaac Asimov

👇🏼 ImageImageImageImage
^ From the world’s best clinical pathologist, Luiz Gonzaga Francisco de Assis Barros D'Elia Zanella, MD, “based on articles reviewing, clinical observations, and high-intensity routine studies and in-hospital COVID-19 patients practice over 8 months”:

"The chronic disease [of… twitter.com/i/web/status/1… ImageImageImageImage
^ From the Top (of the entire thread) ^

^^^^^ UNROLLED ^^^^^

... Niacin in Amino Acid Metabolism
by W. A. KREHL, PhD, MD
Nutrition Laboratory, Department of Physiological Chemistry, Yale University, New Haven, Connecticut

Спасибо, @ringo_ring!


.. Niacin in Amino Acid Metabolism
by W. A. KREHL, PhD, MD
Nutrition Laboratory, Department of Physiological Chemistry, @Yale University

“This serves to re-emphasize the need for evaluating nutritional requirements of an animal not from a simple… twitter.com/i/web/status/1… ImageImageImageImage
... #Cancer #Niacin #FlushNiacin #Glutamine
"According to multivariate logistic regression analysis, niacin intake was negatively associated with mortality outcomes in patients with cancer, with P values below 0.05 in all models. In subgroup analyses based on sex, age, and BMI,… twitter.com/i/web/status/1…
.. Glutamine as a Neuroprotective Agent in Alzheimer's Disease Therapy

Karl Herrup, PhD
Rutgers University

“The central hypothesis of this study is that glutamine has the potential to become a potent agent in the prevention and treatment of Alzheimer's brightfocus.org/grant/glutamin…twitter.com/i/web/status/1…
... “There is a special chapter focused on the recent COVID-19 pandemic: how niacin can help the body recover from infection and reduce the risk of ‘Long COVID.’”

… 💰💰💰 “A striking similarity among studies is that the concentration of glutamate and glutamine consistently increases with progressing lactation”

“glutamic acid (the prevalent FAA) and glutamine increased approximately 2.5 and 20 times, respectively, with progressing… twitter.com/i/web/status/1… ImageImageImageImage

• • •

Missing some Tweet in this thread? You can try to force a refresh

Keep Current with HOM3OSTASIS.com/Protocol

HOM3OSTASIS.com/Protocol Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!


Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @NiacinGlutamine

Mar 24, 2023
Feeding Nicotinic Acid (Niacin) to Dairy Cows
How Feeding Nicotinic Acid (niacin) Can Improve Colostrum Quality and Calf Performance

^ Don’t forget glutamine

Effect of glutamine supplementation on performance, milk composition and some blood metabolites in fresh Holstein cows

Read 7 tweets
Mar 24, 2023
"Recent researches indicate that niacin may be beneficial in the prevention and treatment of aging, cancer, and metabolic illnesses."
Read 4 tweets
Mar 23, 2023
Glutamine and the regulation of intestinal permeability: from bench to bedside
Achamrah, Najate et al in Current Opinion in Clinical Nutrition & Metabolic Care (2017) pp. 86-91
^ "Recent clinical studies underlined that glutamine
may be of interest in patients with irritable bowel
syndrome with predominant diarrhoea (IBS-D) who
frequently exhibit increased intestinal permeability
and altered tight junction protein expression sci-hub.ru/10.1097/mco.00…twitter.com/i/web/status/1…
Read 15 tweets
Mar 23, 2023
Causal Association Between Obesity, Circulating Glutamine Levels, and Depression: A Mendelian Randomization Study
He, Ruixin et al in The Journal of Clinical Endocrinology & Metabolism (2022.12)
...remains unclear whether the interrelationships between obesity, glutamine, and… twitter.com/i/web/status/1…
^ Again: “The present study reported that higher BMI was causally associated with lower glutamine levels. Both obesity and downregulation of glutamine were causally linked to depression.”
Read 6 tweets
Mar 22, 2023
Metformin lmfaoo - that’s literally a fake niacin / GPR109A agonist - that then downregulates GPR109A - what an utter bioterrorism racket

Read 6 tweets
Mar 21, 2023
Oh, you didn’t know it was for our furbabies, who are higher-ordered animals deprived of flush niacin + glutamine too?




👇🏿 Image
^ Come on now, Krehl didn’t teach y’all anything??? You don’t think they put these Nazi nerve agents like ivermectin/Strep-fermenting insecticides and sulfas/hydroxychloroquine in their feeds and “vaccines” too? Why you think they live only to 20 if lucky? You see — a 1-1.5 kg… twitter.com/i/web/status/1… ImageImageImageImage
Read 6 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!


0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy


3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!