Thread by @KetoCounselor

Magnesium is a mineral that is highly abundant in the human body and is considered the second most abundant mineral hanging out in your intracellular spaces. 🧵 (1/11)

Magnesium plays a crucial role as a cofactor in various physiological processes such as protein synthesis, energy production and storage, reproduction, DNA and RNA synthesis, and maintenance of mitochondrial membrane potential. (2/11)

If you want healthy functioning #mitochondria, then you best supplement magnesium. And if you have any cognitive symptoms, it's time to get extra serious about your magnesium supplementation. (3/11)

Studies have discussed the potential positive effects of Mg on several pathological mechanisms of AD. (4/11)

They have shown that Mg can help inhibit the activity of certain enzymes and substances in the brain that contribute to inflammation and damage. (5/11)

Magnesium can help prevent the buildup of amyloid-beta (a protein that forms plaques in the brains of people with Alzheimer's disease) by reducing its influx across the blood-brain barrier. (6/11)

How? It achieves this by decreasing the amount of amyloid-beta that enters the brain from the bloodstream because it inhibits the activity of γsecretase, an enzyme that cleaves amyloid precursor protein (APP) to produce amyloid-beta (Aβ) peptides. (7/11)

And FYI, big #pharma has not developed a safe and effective γ-secretase inhibitor. Prob best to upregulate mitochondrial production and have sufficient micronutrients (like Mg), and then your #mitochondria figure it all out. (8/11)

Magnesium can reduce brain inflammation by inhibiting proinflammatory cytokine TNF-α and IL-1β production, as well as inflammation caused by amyloid-beta. (9/11) #brainhealth #inflammation #Alzheimers

And don't be stingy with the magnesium supplementation. High magnesium levels in the brain can increase the activity of a non-amyloidogenic pathway. Potentially reducing the risk of Alzheimer's by preventing amyloid-beta formation (10/11) #brainhealth #Alzheimers

The bottom line is that magnesium insufficiency or deficiency may pose a risk factor for AD. I like to teach people how to pair it with a ketogenic diet to stop or slow #neurodegenerative processes. (11/11)