Raj Rajnarayanan Profile picture
Mar 26, 2023 12 tweets 12 min read Read on X
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (#15DAYTRENDS):

69.3% XBB.1.5
4.0% XBB.1.5.15
2.6% XBB.1.9.1
1.6% XBB.1.5.13
1.4% BQ.1.1
1.3% XBB.1.5.1
1.3% XBB.1.5.17
1.2% XBB.1.16

#SARSCoV2 Tracker: tinyurl.com/mryj4uu7
Updated: 03/25/2023

1/n
Sequence count by US State

#California and #NewYork have submitted a big share of sequences with specimen collection dates on or after 03/10/2023

XBB.1.5 is still at the top spot;
followed by XBB.1.5.15 & XBB.1.9.1

2/n
Granular details -#VariantDashboard #USA #15DayTrends

XBB.1.5* (VOI - @WHO) is still ahead of the other lineages!

3/n
.@CDCgov updated variant proportions estimates on 03/24/2023 (updated every Friday)

XBB.1.9.1 (parent of EG.1*) makes an entrance!

Prudent to start separately tracking XBB.1.5.13 (parent of EK.1* and EK.2*) and XBB.1.16



4/n
Predicted Immune Escape and ACE2 binding of top lineages in USA (relative to BA.2)

Bivalent boosters (OG/Omicron.BA.5) will potentially protect the boosted from getting severe disease/hospitalizations. Get updated if you haven't already!

public.tableau.com/app/profile/ra…

5/n
USA Airport surveillance update #15DayTrends

111 sequences from 6 US States (#California, #NewYork, #Washington, #NewJersey, #Georgia and #Virginia)

*Includes pooled swabs; Many bad QC seqs

6/n
#Hospital #Capacity - (by State/Division)

All hospitalizations not just COVID-19

public.tableau.com/app/profile/ra…

[Looks like data entry error in DE hospital data]

7/n
#COVID19 #Hospitalizations in the #UnitedStates

>60 yr old & immunocompromised
Have a good look at
@CDCgov
info on #Boosters!

#Ventilate Indoor spaces

Sick? --> Wear a good quality #Mask!

Hospital Tracker (by States, by age group): public.tableau.com/app/profile/ra…

8/n
Circulating recombinant lineages - USA #15DayTrends

XBB.1.5* is still the top recombinant in circulation!

9/n
Status of the latest #COVID19 Wave in #California

Slight increase in hospitalizations

Top circulating lineages in CA (#15DayTrends)

XBB.1.5 (65.2%)
XBB.1.5.15 (6.7%)
XBB.1.9.1 (6.3%)
XBB.1.16 (2.5%)
XBB.1.5.13 (2.2%)
BQ.1.1 (1.9%)
XBB.1.9.2 (1.3%)

10/n
Status of the latest #COVID19 Wave in #NewYork

Top circulating lineages in NY (#15DayTrends)

XBB.1.5 (68.7%)
XBB.1.5.15 (6.9%)
XBB.1.5.1 (2.4%)
XBB.1.5.17 (2.4%)
XBB.1.5.13 (2.0%)
XBB.1.5.16 (2.0%)
BQ.1.1 (1.2%)
EK.2 (1.2%)
..
XBB.1.16 (0.4%)

11/n
Status of the latest #COVID19 Wave in #Washington

Slight increase in hospitalizations!

Top circulating lineages in WA (#15DayTrends)

XBB.1.5 (53.3%)
XBB.1.5.15 (11.1%)
XBB.1.9.2 (11.1%)
CH.1.1 (4.4%)
BQ.1.1.10 (2.2%)
BQ.1.1.63 (2.2%)

[low sequence count]

12/n

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More from @RajlabN

Jun 19
#COVID19 #VariantDashboard - #USA | 06/18/24
#SARSCoV2 #Lineages #30DAYTRENDS

KP.2.3 (7.7%)
KP.2 (7.4%)
KP.3.1 (5%)
KP.3.3 (4.8%)
JN.1.16.1 (4.2%)
LB.1.7 (4%)
JN.1.16 (3.4%)
KP.1.1.1 (3.4%)
LB.1.3 (3.3%)
KP.2.2 (3.1%)
--
KP.3.1.1 (1.5%)👀


1/ntinyurl.com/mryj4uu7
You can filter spike mutations S31del, R346T, L455S, F456L, T572I (Top convergent mutations) to display #SLip, #FLiRT, #TiRT, #FLiRTTI, #DeFLiRT combo mutations; (Note: retired #FLip as of now)

Also, by state, lineage, collection date

2/n Image
#AirportSurveillance data - @CDCgov

Traveler Based Genomic Surveillance Program ( )

New: included "Travel history: Mediterranean Norwegian escape" use sampling strategy menu to display (a KP.5 and KP.2 is reported from WY)

3/n wwwnc.cdc.gov/travel/page/tr…
Image
Read 7 tweets
Jun 9
Tracking #SARSCoV2 #Lineages - Globally |06/08/24

Top lineages -#30DayTrends (#G30)

KP.2.3 (8.7%)
KP.2 (8.7%)
KP.3.1 (7.7%)
KP.3 (6.2%)
KP.3.2 (5.1%)
LB.1 (5%)
KP.1.1 (4.9%)

Track:

1/n public.tableau.com/app/profile/ra…
Image
Granular details #Global #30DayTrends

KP.3* & KP.2* are the dominant group of lineages in the world.

This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 05/09/2024 (8,025 sequences)

2/n Image
@GISAID You can filter spike mutations S31del, R346T, L455S, F456L, T572I (Top convergent mutations) to display #SLip, #FLiRT, #TiRT, #FLiRTTI, #DeFLiRT combo mutations; (Note: retired #FLip as of now)

4/n Image
Read 15 tweets
Jun 5
#SARSCoV2 #VaccineAntigen Updates

Question before @US_FDA #VRBPAC committee:

For the 2024-2025 Formula of #COVID19 vaccines in the U.S., does the committee recommend a monovalent JN.1-lineage vaccine composition?

Watch:

1/n youtube.com/live/weaKQiFk_…
Image
Mutations of Interest on JN.1 background

JN.1 + F456L (FL) |JN.1.16 • JN.1.11.1
JN.1 + R346T (RT) |•JN.1.18 •JN.1.13.1 • KQ.1
JN.1 + R346T + F456L (#FLiRT) |•KP.2 • KP.1.1
JN.1 + R346T + F456L + T572I (#FLiRTTI) |• KZ.1.1.1
JN.1 + F456L + Q493E (#FLuQE) |• KP.3

2/n Image
from @Novavax presentation

JN.1 Vaccine Induces Broad Neutralizing Responses to All Subvariants Tested

3/n Image
Read 4 tweets
Jun 5
#SARSCoV2 Updates

KP.3 group of lineages (as of 6/4/2024) Image
KP.2 (JN.1.11.1 w/ S:R346T) group of lineages (as of 6/4/2024) Image
JN.1* group swells to 266 (not counting recombinants)
Read 4 tweets
May 18
Tracking #SARSCoV2 #Lineages - Globally |05/18/24

Top lineages -#30DayTrends (#G30)

KP.2 (12.7%)
KP.3 (11.6%)👀
JN.1.7 (6.9%)
JN.1 (6.8%)
JN.1.16 (5%)
JN.1.4 (4.9%)
JN.1.16.1 (4.6%)
KP.1.1 (3.6%)
KS.1 (2.8%)
JN.1.32 (2.7%)
LB.1 (2.7%)


1/npublic.tableau.com/app/profile/ra…
Granular details #Global #30DayTrends

KP* is the dominant group of lineages in the world.

This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 04/18/2024 (6,469 sequences)

2/n Image
@GISAID Predicted Immune Escape vs ACE2 Binding Scores of circulating SARSCoV2 lineages (Relative to BA.2)



3/n public.tableau.com/app/profile/ra…
Image
Read 7 tweets
May 6
#COVID19 #VariantDashboard - #USA | 05/05/24

#SARSCoV2 #Lineages #30DAYTRENDS

JN.1.7 (12%)
JN.1 (11.5%)
KP.2 (8.9%)
JN.1.4 (8.4%)
JN.1.13.1 (5.6%)
JN.1.8.1 (4.5%)
JN.1.18 (3.9%)
JN.1.16 (3.6%)
KQ.1 (2.8%)
JN.1.16.1 (2.7%)
KP.3 (2.2%)

||
1/ntinyurl.com/mryj4uu7
Sequence count by US States

A total of 1886 sequences were submitted with specimen collection dates on or after 04/04/2024 (of which 373 (~19.8%) were collected via airport surveillance)

2/n Image
Predicted #ImmuneEscape vs ACE2 Binding Scores (Relative to BA.2)



3/n public.tableau.com/app/profile/ra…
Image
Read 6 tweets

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