JM Rothberg Profile picture
Fast (Next-Gen) DNA sequencing, Ultrasound-on-a-Chip, Portable MRI, Next-Gen Protein Sequencing, Biological Recycling.
Jan 14, 2021 6 tweets 3 min read
1/6 @quantum_si represents the next logical step for my work in massively-parallel DNA sequencing (next-generation DNA sequencing, NGS) and proteomics. My teams created the NGS field in 2005 (454 Life Sciences) and with it changed life sciences and medicine forever. ImageImage 2/6 We had the covers of both Nature and Science for our proteomics work, and were first to move NGS onto a semiconductor chip with Ion Torrent. ImageImage
May 24, 2020 4 tweets 3 min read
Super exciting day. 78 days ago saw my lab and thought we need to help fight #Covid. Today I’m running our Covid Detect At-Home test. A sensitive presymptomatic molecular test for the rest of us. Scaling as I tweet to millions & 10s of million per month. Just ran Covid Detect At-Home test for the first time on myself!

So simple. Swab and go!
and...

Well I’m human, the nose collection control worked (we test for human gene).

And I’m NOT positive for #Covid.

Total Game changer!

Real molecular testing anywhere. By anyone.
Mar 17, 2020 11 tweets 11 min read
Reporting progress on #coronavirus Home Test from our teams internal email: Just wanted to give a brief update from the #molbio team as we build momentum towards delivering an at-home, user-friendly, rapid #COVID19 test...We are actually detecting Covid19 #RNA in solution now! 1/ ... we got early proof today that we can do reactions from RNA (the genetics code of #SARSーCoVー2 not DNA so it’s more insidious). Our method (which amplified the RNA without a machine) is very tolerant of #saliva - (we still have to crack open the virus RNA for full proof) 2/
Mar 7, 2020 31 tweets 27 min read
Thinking about a low cost easy to manufacture home test kit for #Coronavirus. Outline: #Nasal_swab (Q-tip) w/ freeze dried reagents for isothermal #DNA amplification with #COVID19 primers. Colorimetric readout by #iOS or #Android #App w/ #geolocation & #HIPPA compliant reporting. Image Read-out would be in minutes - timer in App - read by camera in your smart phone. No other machines. Links to telemedicine groups for positive results. Built in positive control - e.g. no color = improper test, green NEGATIVE, red POSITIVE.