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Omar Mossad
@OmarMglia
PhD candidate, microbiome and microglia interaction #neuroimmunology #gutbrainaxis
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Mar 8, 2022
•
13 tweets
•
10 min read
Does
#gut
#microbiota
interact with
#microglia
in the
#aging
#brain
? Are microglia metabolically affected (
#mitochondria
)? Does
#diet
take part? any
#translational
data?
Our paper made it last week in
@NatureNeuro
so it's about time for a 🧵!
nature.com/articles/s4159…
1.
Microglia from aged and young-adult
#male
&
#female
mice, under SPF or
#germ_free
conditions were profiled by bulk
#RNAseq
. We identified a gene-set, which depended on the housing condition regardless of
#age
& regulate central processes in microglia. "Microglial GF signature"