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Mohamed ElTanbouly Profile picture
Mohamed ElTanbouly
@Plasmacellguy
Immunologist
2 subscribers
Nov 10, 2023 • 25 tweets • 15 min read
1/Where do I start?

Is it at Von Behring and Kitasato who were the first to discover that immunization of animals with diptheria and tetanus toxins resulted in soluble substances in the serum that neutralize these same toxins making them harmless?
bit.ly/VonBehring1890

From "The generative grammar of the immune system" by Niels K Jerne (EMBO, 1985) PMID: 2410261 Also see his Nobel lecture of the same title. 2/Which later led to a big development in anti-sera therapeutics against multiple diseases

e.g. J. Bordet's work on cholera

(nicely summarized here )bit.ly/Bordet1895
bit.ly/Bordetsummary
Mar 29, 2023 • 17 tweets • 7 min read
(1) The plasma cell (PC) field has been booming and blooming in the past two years

Some dogmas and notions were quietly taken apart

An #immunology 🧵 (2) First, a pervasive dogma was that germinal centers are the sole origin of long-lived PCs

There is accumulating evidence that LLPCs can originate from T-cell-independent (extrafollicular) responses

bit.ly/Fidler1975
bit.ly/Bortnik2012
bit.ly/Bortnik2013 Figure 1 from PMID: 22529295
Mar 1, 2022 • 18 tweets • 10 min read
(1) A lot of Immunologists are (justifiably) obsessed with T cell exhaustion.

Very few discuss memory inflation 📈 despite its relevance to #vaccines and #aging

#Immunology #TCELL

Diagram and background info mainly from bit.ly/OHara2012 (2) Inflation: induction of memory [CD8+] T cells that increase in frequency over time to >10% of the entire T cell pool in blood and higher abundance in peripheral tissues (e.g. liver and lung)
Jan 25, 2022 • 17 tweets • 5 min read
1/Truly inspiring and [by far] my favorite talk (so far) @Midwinter_Immun

quick 🧵 2/Kagan and co. address the outstanding question: How can you activate and program a dendritic cell to promote protective (including antitumor) immunity?

Same as, why have DC-based vaccines and all cancer vaccines failed thus far?
Sep 9, 2021 • 21 tweets • 21 min read
Inspired by @philipcball's question, here is a 🧵of some of the most beautiful #biology experiments (in my opinion)

Disclaimer: Not in order and no details (links provided) 1-Messelson-Stahl discovery of semi-conservative DNA replication (Okay that's obvious but bear with me)

Year: 1958

Side-note: notice how humble the paper title is.

Paper ➡️pnas.org/content/44/7/6…

Summaries ➡️
➡️
Oct 20, 2020 • 9 tweets • 3 min read
Our review on peripheral T cell tolerance is now online in @NatRevImmunol

Link rdcu.be/b8LRt

I want to state a few relevant points in this 🧵

#Science #Immunology #AcademicTwitter Image Most studies and perspectives focus on one mechanism of tolerance and few have seriously considered all these together in the context of T cell differentiation.

We attempted to draw a conceptual framework for the known tolerance checkpoints at each stage of the T cell lifespan