2/ I did a quick search to find the first time “talc granulomatosis” was used as a term for lung lesions caused by excipients in pills, and came across this 1970 paper. Were Hopkins and Taylor the first to coin the term? Correct me if I’m wrong @yro854
Here are 10 cryptic clues to this diagnosis: 1. Georgina, William and Arthur 2. Chest pain 3. 17p11.2 4. Larger, lower 5. Canada 6. Face 7. No cathepsin 8. It's ok to be a man 9. Nothing in the wall 10. Epidermolysis bullosa, ichthyosis, neurofibromatosis
Clues explained: 1. Georgina, William and Arthur (first names of Birt, Hogg and Dube) 2. Chest pain (from pneumothorax) 3. 17p11.2 (FLCN gene) 4. Larger, lower (cysts larger than LAM with predisposition for lower lobes..
5. Canadian authors 6. Face (where fibrofolliculomas occur) 7. No cathepsin (cathepsin is pos in LAM not BHD) 8. It's ok to be a man (LAM is super rare in men, not BHD) 9. Nothing in the wall (unlike LAM, where cysts contain abnormal smooth ms cells)
Here are the 4 winners for #PathTweetAward All will get awards but we need to rank, so pls pick your favorites! First, the 2 winners in the open category. Please scroll down in the thread to see the actual award winning tweets. Scroll further down to see trainee awardees.
1/ This is the beginning of a #tweetorial or #pathtweetorial on a mystery topic. Fear not, it’ll become evident soon what we’re talking about. But first I’ll show you an image. These serpiginous fibroblast plugs are diagnostic if organizing pneumonia (formerly BOOP)
2/ In MOST cases of organizing pneumonia seen on lung biopsy, the etiology is not evident on histology. But sometimes, there is a clue. Examine this pic closely and then see if you can answer the quiz in the next tweet in this thread.
You are at risk if you live in the Ohio or Mississippi River valleys, go spelunking, or work with chicken coops
Many (maybe most) people who inhale Histoplasma remain asymptomatic. Many have symptoms that mimic “the flu” and are treated as such. Only a minority of immunocompetent folks are seriously and acutely ill at first exposure. This is called acute pulmonary histoplasmosis.
What do you think happens next in the vast majority of infected individuals?
1/ It’s time for a #tweetorial on hypersensitivity pneumonitis. It’s a greatly misunderstood entity. Potentially treatable, so can be very good news. OTOH, misdiagnosing UIP as chronic hypersensitivity pneumonitis can be very bad.
It had great tips, like this one: ALWAYS include a picture of yourself on your profile. He’s right: please do it NOW! It’s essential. Just use a selfie 😊
Follow a few pathologists. Use this handy guide created by @RoseannIWu to begin with, and then just follow people whose tweets you like. Following is a friendly gesture on Twitter, and conveys that you are interested that person’s tweets.