Thread by @gerdosi

Researchers are amused by the differences in fat absorption. Also, they think that the only problem with the following meal is the amount of fat.
“a small hamburger, small fries, and a small ice cream shake with fruit”
Let me explain it briefly. 1/n

ars.usda.gov/news-events/ne…

Refined wheat flour, cooked potatoes, the sugar in the shake contain a lot of quick-absorbing glucose. These maintain a bacterial population in the small intestine that is rich in Gram negative LPS producers. The long-chain fat in the diet helps the LPS get into chylomicrons. 2/n

What's more, simple sugars speed up chylomicron formation, pushing even more LPS into the lymphatics.
Now, what would be the best strategy to minimize this effect? (NB, some LPS translocation is perfectly fine.) Have you considered why LCFA are absorbed into lymph at all? 3/n

Both CM and VLDL contain LPS binding protein (LBP) that can hide LPS (+flagellin and other debris) and gradually deliver it to tissues (mainly the liver) where moderate amounts are easily neutralized. CM get a first pass in the lymphatics, so that the liver is not overloaded. 4/n

What you can do is either minimize LPS production (Gram- overgrowth in the small intestine), or eliminate substantial amounts of LCFA that help LPS uptake into CM. Voila, both very low carb and very low fat diets plausibly work, and the swampland in the middle is explained. 5/n