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Gabor Erdosi /erdoke
@gerdosi
, 13 tweets, 5 min read Read on Twitter
Several recent studies/reviews highlight the importance of chronically suppressed autophagy in driving chronic diseases of civilization.
cell.com/cell-reports/f…
ebiomedicine.com/article/S2352-…
emboj.embopress.org/content/early/…
cell.com/cell-reports/f…
nature.com/articles/s4157…
frontiersin.org/articles/10.33…
And another review out in Cell.
cell.com/cell/fulltext/…
Chronically suppressed autophagy ⇄ chronic inflammation. Chronic hyperinsulinemia is just a tool to maintain the necessary metabolic support.
A new study in Nature further refines our understanding of autophagy.
nature.com/articles/s4158…
Chronically suppressed mitophagy may be a main underlying problem of Alzheimer’s pathology.
nature.com/articles/s4159…
Nutrient excess and autophagic deficiency: explaining metabolic diseases in obesity
metabolismjournal.com/article/S0026-…
“Novel genetic locus near ATG5 regulates preferential accumulation of visceral (vs. subcutaneous) fat in youth and adulthood, and it contributes to the development of systemic inflammation in adulthood.”
academic.oup.com/jcem/advance-a…
Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes
link.springer.com/article/10.100…
The potential role of (the lack of) mitophagy in (mitochondrial) aging.
ncbi.nlm.nih.gov/pmc/articles/P…
mTOR independent activation of autophagy by rapamycin.
journals.plos.org/plosbiology/ar…
Perhaps even baldness is related to insufficient autophagy?
Stimulation of Hair Growth by Small Molecules That Activate Autophagy
Cell Reports 27, no. 12 (June 18, 2019): 3413-3421.e3. doi.org/10.1016/j.celr….
“autophagy deficiency in dendritic cells can compromise the stability and function of Tregs and precipitate autoimmune and inflammatory disorders.”
Whenever I feel that a flare-up of my AS is imminent I just skip a few meals. It works every_single_time.
cell.com/cell-reports/f…
“Defective removal of damaged mitochondria leads to hyperactivation of inflammatory signaling pathways and subsequently to chronic systemic inflammation and development of inflammatory diseases.”
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Gabor Erdosi /erdoke
@gerdosi
What renders your HDL pro-atherogenic? The acute phase response, or more precisely, serum amyloid A (SAA), that displaces ApoA-I in HDL. Beautiful ‘design’ to deal with infection/infiltration, but a huge problem if the trigger remains unresolved.
ahajournals.org/doi/full/10.11…
The same underlying cause of high CVD mortality in late- and end-stage renal disease.
jasn.asnjournals.org/content/23/5/9…
Serum amyloid A impairs the antiinflammatory properties of HDL jci.org/articles/view/…
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