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#COVID19: 3655 #SARSCoV2 genomes have been sampled.

On the left, strains are organized by the number of mutations.

On the right, strains are organized by time.

The US has the greatest concentration of divergent strains, including ones branching from the most #lethal strains...
On the left, you can see which regions are the most mutated. "S" (~21,750 - ~25500) corresponds to the S1 and S2 spike protein fragments and there appears to be one major mutant site there. On the right, you can see a world map of all strains.

#COVID19

nextstrain.org/ncov/global
In contrast, the flu is much more slowly evolving, with only 6 dominant strains as of 2019.

The #flu also doesn't have the same immune cloaking mechanisms as #SARSCoV2 and is evenly distributed across the world.

Stop comparing the flu to SARS.

nextstrain.org/flu/seasonal/h…
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#COVID19 #SARSCoV2 #lethal #flu

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Andre Watson 🧬💊💉
@nanogenomic
(1/6) Most drugs are not effective at treating #COVID, and do not address the root-cause symptoms. #Remdesivir is one such example—the drug mimics #RNA, and gets incorporated into the viral RNA transcripts preferentially versus human RNA transcripts.
(2/6) Mechanistically, this drug was promsising. However, in today’s @TheLancet paper, "#Remdesivir in adults with severe #COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial," findings are inconclusive at best, and damning at worst:
(3/6)
1) The study enrolled already-hospitalized patients with pneumonia, with <94% oxygen saturation, who were already hospitalized
2) They measured clinical improvement for 28 days
3) "#Remdesivir use was not associated with a difference in time to clinical improvement"
Read 6 tweets
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Andre Watson 🧬💊💉
@nanogenomic
(1/8) #ACE2, which also likely coats the virus and hijacks the B(0)AT1 / #SLC6A19 amino acid transporter pathway, is the viral entry mechanism for #SARSCoV2. ACE2 is a co-receptor with SLC6A19. Hartnup disease (en.wikipedia.org/wiki/Hartnup_d…) is characterized by mutations in #SLC6A19.
(2/8) If #SARSCoV2 #COVID #coronavirus is interfering with the ACE2-B(0)AT1 complex (see structural data below and at biorxiv.org/content/10.110…), and/or collectrin (which shares significant homology with ACE2 and is an unexplored potential mechanism of entry for SARS as well)...
(3/8) ...it is mechanistically likely that we will see many symptoms of #COVID19 / #COVID / #CORONAVIRUS / #SARSCoV2 that overlap with Hartnup disease.

"Excessive amounts of amino acids, such as tryptophan, are excreted in the urine."
Read 9 tweets
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Andre Watson 🧬
@nanogenomic
(1/8) The cycle of repression of factual information, denial of factual information and legitimate inquiry leaked or posed through sources other than primary news sources, evidence digging by scientists, further cycles of repression and denial, attacks on credibility and... Image
(2/8) ...reputations of those who speak out, and slow unrolling of the truth has never been clearer, or more exemplified, than by the COVID outbreak.
We will look back at this like the #Snowden leaks, only with far less controversy. #COVID is a crime against humanity.
(3/8) The #truth will find its way out. In the meantime, wake up. This story goes deeper than most even begin to realize.
I have put my career and reputation on the line to unearth the truth and push for developing #vaccines and therapeutics against COVID.
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