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The amount of #SARSCoV2 detected in #COVID19 patients was the highest in the first week when symptoms appeared, according to an @HKUMed study, which analysed saliva samples from 23 lab-confirmed patients to track their viral load as the disease progressed. (1/4)
They also studied immune response through blood samples.

Antibodies were detected 10 days after symptom onset and the viral load gradually declined as more antibodies were produced; but the virus was still detectable in a third of #COVID19 patients studied after 3 weeks. (2/4)
Key takeaways:

▶️ Median time between symptom onset to hospitalisation was 4 days
▶️ Older #COVID19 patients & those with severe disease had a higher viral load
▶️ Underlying chronic illness did not affect the viral load of #SARSCoV2

(3/4)
Such data can guide study on antiviral treatment, vaccine, control measures, etc.

Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by #SARSCoV2: an observational cohort study (4/4)

thelancet.com/journals/lanin…
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Related hashtags

#SARSCoV2 #COVID19

More from @hkumed see all

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HKU Medicine
@hkumed
A study from @hkumed in @AGA_Gastro found traces of #SARSCoV2 in stool samples from 9 of the 59 studied #COVID19 patients in #HongKong, suggesting that the virus may be able to spread via the ‘fecal-oral route’. (1/5)
Key takeaways:

▶ #SARSCoV2 was found in stool samples even in patients who did not show any gut symptoms.
▶ #COVID19 patients who had diarrhoea had more viral RNA in their stool.

(2/5)
The study also analysed 4,243 #COVID19 patients from 6 countries and found that 17.6% of them also had gut symptoms, including eating problems, vomiting, diarrhoea and stomach ache. (3/5)
Read 5 tweets
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HKU Medicine
@hkumed
A team from @hkumed studied how #SarsCoV2 infects and multiplies in human lung tissues. The study compared the virus with SARS-CoV, the #coronavirus responsible for the 2003 SARS outbreak, on how they attacked human lung tissue. #COVID19 Image
Key takeaways from the study:

► #SarsCoV2 and SARS-CoV infected the same types of cells in the lungs.
► #SarsCoV2 was more capable of infecting lung tissue than SARS-CoV. #COVID19
► Once infected, #SarsCoV2 multiplied 3.2 times faster than SARS-CoV in 48 hours, explaining the rapid spread of the virus during the early stages of infection.
► The immune system had a poor response to #SarsCoV2, which allowed this virus to infect and multiply better.#COVID19
Read 4 tweets
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HKU Medicine
@hkumed
Q: Are disinfectants effective in causing #SARS_COV_2 to lose infectivity?

A: The @hkumed team tested a wide variety of different disinfectants and found that all the following were effective in causing viruses to lose infectivity after 5 minutes of use. #COVID19 #KnowTheFacts Image
For more on the study by Professor Leo Poon, Professor Malik Peiris of @hkumed & others.

thelancet.com/journals/lanmi…
Q: Do different surfaces affect the time it takes for #SARSCOV2 to lose infectivity?

A: @hkumed tested how long it would take for the virus to lose infectivity on different surfaces. #COVID19

(Correction: Early version said infectivity is lost on glass in 2 days instead of 4) Image
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