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In our @LancetMicrobe paper we report 671 Mtb genomes 🧬from 391 patients with drug #resistant #tuberculosis in KwaZulu-Natal South Africa sampled over 6 years.

We screened for resistance to #bedaquiline, a drug now central to effective #TB treatment.

➡️tinyurl.com/y5zapnbk
We found ~4% of patients harboured #Mtb with variants in genes known to mediate #resistance to bedaquiline/clofazimine.

Phylogenetic analyses show repeated & independent acquisitions of resistance variants, including onward transmission of resistant strains across South Africa.
Bedaquiline is a reasonably new, but now cornerstone, drug in the fight against #DRTB.

The lack of routine #bedaquiline susceptibility testing may allow these #resistant strains to continue to spread, unwatched, posing further significant challenges to #TB treatment & control.
Important work led by @Camusnimmo with @JamesMillard13 @BallouxFrancois @UGI_at_UCL
et (many) al.

Also see here for a great overview and summary of our work:
➡️thelancet.com/journals/lanmi…

#StopTB #EndTB #drugresistance #AMR
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#resistant #tuberculosis #bedaquiline #TB #Mtb #resistance #DRTB #StopTB #EndTB #drugresistance #AMR

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Lucy van Dorp
@LucyvanDorp
Our paper on the emergence of genomic diversity and recurrent mutations in #SARSCoV2 is now out in #IGE tinyurl.com/yb4mxhes As with many others, we’ve been working hard tracing the evolution of #SARSCoV2 using thousands of genomes 🧬shared on @GISAID. Here's what we found👇/1
Here we analyse >7500 viral genomes from all around the 🗺️ We show that the time of the host-jump of #SARSCoV2 into humans dates to late last year, consistent with estimates by several others

Genetic data shows #SARSCoV2 only recently started infecting us & was detected fast. /2
Around the world we see large amounts of regional genetic diversity with marked & repeated intros to many countries

Eg. we place genomes sampled from UK patients throughout the global tree. There is no such concept as a patient zero (see @nextstrain also for visualisations) /3
Read 8 tweets
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Lucy van Dorp
@LucyvanDorp
Our work is now officially out in @MolBioEvol: #Malaria viewed through the lens of an eradicated European strain tinyurl.com/qkqmaxe. (1/7) #published #genomics
On our hunt for past malaria we were fortunate to obtain a collection of blood-stained medical #microscope #slides prepared for diagnostics purposes in 1944 in Spain, one of the last footholds of #malaria in Europe. (2/7)
From these slides, and with a bit of lab wizardry from the team @uni_copenhagen @IBE_Barcelona, we were able to obtain a full #Pvivax genome - we also obtained a #Pfalciparum partial genome tinyurl.com/y2wsljcj. (3/7)
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