The interaction of #Ecoli O157 :H7 and #Salmonella Typhimurium #flagella with host cell #membranes and cytoskeletal components | #Microbiology #Pathogenesis #Thread
microbiologyresearch.org/content/journa…
![](https://pbs.twimg.com/media/EhUJQLBXsAEN2rZ.png)
Jo Elvidge and I were looking at the role of #flagella in early infection of #Salmonella and #Ecoli in relevant animal tissue models (🐖🐄)
We spotted what looked like very intimate adherence...
![E.coli O157:H7 on Bovine terminal rectal cells](https://pbs.twimg.com/media/EhUO8TSWkAgiJZF.png)
![Salmonella Typhimurium on porcine epithelial cells](https://pbs.twimg.com/media/EhUO8TRXsAY2-N4.png)
But with confocal we couldn't look closely enough...
And guess what?!
#Membranes were being deformed by #flagella to form channels - so the flagella looked like they were inside by #confocal, but weren't really...
![Salmonella flagella bundles technically still outside of the](https://pbs.twimg.com/media/EhUTE0wXgAYGrs3.png)
[Spoiler - we still don't know for sure because it's such a technically tricky thing to observe, but maybe flagella can disrupt host cell membranes?]
#flagella #adherence #Pathogenesis