Thread by @eliza_coli

#Haemolysis data indicates that #disruption of host cell #membranes by rotating #flagella is physically possible, despite what previously published measurements with firing gold nanobeads at tissue cultures tells us.

[Pls read the paper for the more complex story with E.coli]

But what if #flagella did penetrate host cell #membranes? What might that mean?

Well, in vitro at least, #Ecoli and #Salmonella #flagella can enhance #actin #polymerization rates. Interactions with #Cofilin-1 (CFL) had an additive effect...

#Flagella induced #actin polymerisation is an intriguing possibility, especially given the actin rearranging lifestyles of these #pathogens.

However, I will always be the first person to point out #caveats in this (finally published) study.

[Please read the insanely long #discussion]

I didn't nail this piece of science. But I really wanted to share what we found, because maybe you will. #AcademicChatter

I need to thank about a bajillion awesome ppl (have you seen how many authors there are on this paper?!), but thanks especially to @strain9000
for some seriously long term support in getting this out there. #mentor

@strain9000 This has been quite a slog (not just the thread 😉 ) - these days I'm a full time scientific illustrator!

Please check out my website if you're interested in any #microbiology #SciArt
lizawolfson.co.uk

@strain9000 @threadreaderapp unroll