Discover and read the best of Twitter Threads about #microbiology

Most recents (17)

#Haemolysis data indicates that #disruption of host cell #membranes by rotating #flagella is physically possible, despite what previously published measurements with firing gold nanobeads at tissue cultures tells us.

[Pls read the paper for the more complex story with E.coli]
But what if #flagella did penetrate host cell #membranes? What might that mean?
Well, in vitro at least, #Ecoli and #Salmonella #flagella can enhance #actin #polymerization rates. Interactions with #Cofilin-1 (CFL) had an additive effect... Actin polymerisation rates with flagella from E. coli (H6, H
Read 8 tweets
8 years since the first manuscript draft but it's finally here!

The interaction of #Ecoli O157 :H7 and #Salmonella Typhimurium #flagella with host cell #membranes and cytoskeletal components | #Microbiology #Pathogenesis #Thread

microbiologyresearch.org/content/journa…
@strain9000 @ArielBlocker @MicrobioSoc This all started many 🌑🌒🌓🌔🌕🌖🌗🌘🌑 ago...

Jo Elvidge and I were looking at the role of #flagella in early infection of #Salmonella and #Ecoli in relevant animal tissue models (🐖🐄)

We spotted what looked like very intimate adherence... E.coli O157:H7 on Bovine terminal rectal cellsSalmonella Typhimurium on porcine epithelial cells
It was a toughie to quantify back then with the tools we had, but every time we looked, we saw it 🤓
Read 9 tweets
1/5
African S. Typhimurium ST313 has 23 Lineage 2-specific pseudogenes, discovered by @DrRobKingsley in 2009, inc ybjZ.

But what is function?

In collab with Jared Honeycutt @monack_lab, we've discovered that MacB (YbjZ) influences pathogenesis of ST313

journals.plos.org/plospathogens/…
2/5
Genomes of 285 S. Typhimurium isolates revealed lineage-specific SNPs = macA & macB are pseudogenes

Suggesting that MacAB-TolC efflux pump is functional in S. Typhimurium ST19, but defective in ST313 Lineages 1 & 2
3/5
Beautiful expts designed by Jared Honeycutt & @monack_lab show MacA variant & truncated MacB protein made ST19 sensitive to C18G antimicrobial peptide

& the ST313 macAB SNPs reduced intra-macrophage replication & fitness in murine GI tract

See @monack_lab tweet for details
Read 6 tweets
Ok, sort of weird to say...but today I'm dedicating some time to SPIT (formally known as #Saliva). It's the super hot topic this week in the ever-changing #COVID19 diagnostic landscape we are living in, so let's take a quick peek at some of the evidence out there (thread)
I completely understand the importance of testing saliva, particularly as it relates to lack of supplies and resources. It can be a feasible option that basically eliminates HCW risk of infxn during collection. It can also save supplies: no swabs, media, possibly fewer reagents.
First paper is here: DOI: 10.1128/JCM.01659-20
-53 paired samples from OP and/or NP swabs, and saliva were collected
-Standard RNA extraction methods were used for the swab samples, a quick extraction method was used for saliva. Handling high-viscosity samples is discussed.
Read 20 tweets
Daily Bookmarks to GAVNet 07/30/2020 greeneracresvaluenetwork.wordpress.com/2020/07/30/dai…
Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic | Nature Microbiology

nature.com/articles/s4156…

#pandemic #evolutionary #origins #microbiology
Strike 1: Gold; Strike 2: Dollar; Strike 3: Inflation Expectations – Alhambra Investments

alhambrapartners.com/2020/07/28/str…

#inflation #gold #expectations #investments
Read 6 tweets
I just want to be clear: while I understand and have similar frustrations with turnaround times for #COVIDー19 testing, I'm afraid the angst is falling on the laboratories...and I do not feel that is fair or appropriate. (Small thread)
The clinical laboratory is full of living, breathing, intelligent human beings. The work takes skill and time. Often, labs are understaffed and there has been a shortage of trained clinical lab scientists FOR A WHILE. There are only so many tests a person can crank out in a day.
Even if a lab has all the staff they need, there's only so much testing that can be done when a) your instruments are full b) you cannot get the supplies you need to run these tests. Seems like many people think labs have unlimited access to very expensive instruments...nope.
Read 8 tweets
Hey, friends. Here's what's up in the world of #COVID19 literature from the last 24 hours (7/23). Simple summaries provided, as always, follow the link for original manuscripts. BE WELL! #IDtwitter #MedED #MedTwitter #Microbiology #InfectiousDiseases
1. Title: Addendum to: Children are not COVID-19 super spreaders: time to go back to school
Link: adc.bmj.com/content/archdi…
Brief Study Design: This is a letter (addendum) to the author’s original research paper (cited in the letter and can be accessed from it).
Simple Summary: Contact-tracing studies have demonstrated that children have a significantly lower attack rate of COVID-19 compared to adults.
Read 43 tweets
Looking for ways to bring discussions of #racism in your #science classes? Some ideas I use in class & in talks e.g. genome-wide sequencing studies, databases are skewed. Must be accounted for when extrapolating these data (e.g. personalized medicine) nature.com/news/genomics-… 1/n
Especially when those findings are used to develop decision #algorithms otherwise #racism gets "baked in" #ArtificialIntelligence is not neutral. Healthcare outcomes reflect societal racism nature.com/articles/d4158…
2/n
Which means that structural #racism can kill #cancer patients "Black patients with breast cancer and other malignancies face historical inequities that are ingrained but not inevitable" acsjournals.onlinelibrary.wiley.com/doi/full/10.10…
3/n
Read 16 tweets
سلسلة هذه التغريدات توضح بعض المصطلحات الطبية المستخدمة بشكل كبير في مجال جينوم البكتيريا
(Bacteriol genomes 🧬 )
:
#بكتيريا #علوم_طبية
#microbiology #genome #gene #InfectiousDisease #Biotechnology #biology
#ثريد #مختبرات_طبية
1- Agglutination: يعبر عن تجمع البكتيريا و الاجسام المضادة المغلفة بـ اللاتكس عند وجود مستضد/ (antigen ) معين.
2- Antimicrobial: يعبر عن العامل الذي يقتل او يمنع الكائنات الحية الدقيقة من النمو من بكتيريا، فيروسات وفطريات.
Read 26 tweets
[FR, ENG below] Hello Twitter !
Je suis Louis, bientôt diplômé en #écologie et #épidémiologie des maladies transmissibles, et à ce titre, je recherche une #thèse pour la rentrée 2020 !
Mon CV est juste là 👇
Les RT sont évidemment très appréciés !
Je souhaiterais étudier les 1/9 Image
maladies infectieuses humaines liées à l'urbanisation et aux contextes urbains, soit dues aux concentrations de populations, soit aux avancées technologiques (maladies dues aux contaminations de réseaux d'eau et leur épidémio, par exemple). Les maladies sexuellement 2/9
transmissibles m'intéressent beaucoup, et je suis également très attiré par les aspects de spatialisation/SIG, et la sociologie des maladies transmissibles (comportement, perception des risques, ...). Mes agents pathogènes de prédilection sont les parasites, les bactéries et 3/9
Read 9 tweets
And finally, congrats to our 2019 #AgarArt Professional winners! People's Choice w/ the most FB 'likes' goes to "Hungarian Folk Art," Zita Pöstényi, Microbiologist, SYNLAB Hungary Ltd., #Budapest, Hungary. #microbiology #sciart #bioart #bacteria #folkart #clinmicro Image
2019 #AgarArt Professional, 3rd place: "Fu(n)ji-san," Isabel Franco Castillo, Ph.D. Student, @ICMA_Aragon (ICMA-CSIC/UNIZAR & CIBER-BBN), #Zaragoza, Spain. #fungi #fungus #spores Image
2019 #AgarArt Professional, 2nd place (TIE): "Ablution," Michael V. Magaogao, Senior Lab Tech, RAK Medical & Health Sciences University, Ras Al Khaimah, #UAE. "The #NotoriousRBG on V.R.B.G.," Michael Taveirne, Ph.D., Teaching Asst Professor, @NCState, #Raleigh, NC. ImageImage
Read 5 tweets
Today on #MitoMonday we briefly highlight Dr Julius Richard Petri and the story of his invention that bears his name. #LateNightWithTheRutterLab #MidNightEdition
Dr. Julius Petri was born in the city of Barmen, Germany on the 31st of May 1852. He received his medical training at the Kaiser Wilhelm-Academy for military physicians in Berlin and earned his doctorate in medicine in 1876. He would practice as a military physician till 1882. 2/
Dr. Petri was assigned to a research facility called the Imperial Health Office in Berlin from 1877 to 1879 where he served as the lab assistant to Dr. Robert Koch, aka the father of modern #microbiology. 3/
Read 14 tweets
Happy Monday! Here is the second thread on Twitter for science organizations. Today we will discuss tweets - how to craft them, how to use hashtags, mentions and quote tweets @PrinSciAdvGoI

For our first thread in this series click here -
The one thing to take away from this thread is this - All tweets are public interactions. Not only are they interactions with the public, but tweets are also public information. A social media rep speaks on behalf of the organisation. Keep personal opinions for personal accounts
Write full sentences but be as brief as possible. Only use commonly known abbreviations - if necessary, expand them. Do not use too much scientific jargon - remember you are reaching out to the general public, not a group of scientists.
Read 9 tweets
Our recent work uses #kefir – a natural milk fermenting community – to unravel mechanisms of coexistence in complex communities. Now on bioRxiv: biorxiv.org/content/10.110… (thread 1/5)
We show how microbes poorly suited for milk surprisingly dominate the kefir community through metabolic cooperation. The kefir grain acts as a ‘basecamp’ for this complex community (30-50 species), from which they colonize the milk in a complex yet organized manner (thread 2/5)
The ability of the microbial species in kefir to stick together and collaborate is what makes them successful, e.g. by being more stress resistant. This image shows one of the interaction networks we uncovered for kefir species
(thread 3/5)
Read 5 tweets
Sharing #MyStory as an #international #immigrant a part of @IWS_Network #Voices without #Frontiers initiative! As a #scientist and an advocate for #workplaceequality, I believe in the power of stories. #IWS #VoicesIWS #SayItForward #WomenInspire #WomeninScience #WomenInSTEM
As a child, how would you have liked moving schools in new cities with different cultures every 2-4 years?

Growing up in the #IndianArmy, I absolutely loved it! By the time I was 18, we had moved over 9 times across 9 states! #Diversity #India #TravelTuesday #IWS #VoicesIWS
My #memories of #India include sunny days, welcoming people, rich heritage, vibrant colors, abundant fruits and mouth-watering street food! #IWS #VoicesIWS
Read 39 tweets
It doesn’t seem to be as easy as it looks like 😋
My version 🤠
Its definitely worse than the last time 🍳
1. Its over cooked from the outside.
2. Runny from the inside.
Possibilities why it went wrong:
1. Very hot pan to start with?
2. No enough scrambling?
Positives:
It tastes good to me😋
Take those points in account & try again next week.
Read 7 tweets
We’re running a live Outbreak Control exercise w reps from @RCTCouncil @swpolice @WelshGovernment @CV_UHB @CwmTaf @H_S_E & PHW! #WPHC17
This exercise is live and unscripted - a demonstration of the serious and immediate nature of high-risk public health scenarios. #WPHC17
The scenario: microbiology has confirmed 4 cases of an infectious disease within 1 week; 1 deceased, no clear link between cases. #WPHC17
Read 57 tweets

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