🔴HOW DOES THIS CHILD GO 8 YEARS WITHOUT A DIAGNOSIS? She has textbook ICHD-3 #migraine! 1>sudden hypersensitivity (smell) 2>throbbing #pain 3>nausea 4>need for bedrest
🟡#SinusHeadache is accompanied by symptoms of infection like fever or pus. 90% of people who think they have sinus #headache have #migraine. 40% of people DIAGNOSED w/ sinus headache have migraine.
Recurrent #pain accompanied by hypersensitivity &/or nausea is likely migraine.
.@WHO used objective metrics to determine the #disability classes used in the Annual Global Burden of Disease Reports. Severe #migraine ranks in the highest class alongside active psychosis & terminal-stage #cancer. Early diagnosis & effective treatment can protect people.
#Headache is #migraine's most common symptom, but it's a highly variable neurological disease, & people who don't have headaches can be disabled by migraine. ICHD-3 notes this, but still classifies the disease as a headache disorder. See the APPENDIX, too. ichd-3.org/1-migraine/
.@PeterGoadsby et al's "Pathophysiology of #Migraine: a Disorder of Sensory Processing" (2017) is a magisterial, accessible review of migraine research. With 883 references, it's been indispensable in our advocacy. ncbi.nlm.nih.gov/pmc/articles/P…
Goadsby et al: The “most disabling of all neurological disorders," #migraine is "largely accepted to be an inherited tendency for the brain to lose control of its inputs." 1/2
Goadsby et al: "At its core, #migraine is a disorder of the brain caused by a dysfunction in areas ... that alter the perception of sensory inputs & cause other neurological deficits.” 2/2
1 in 7 people worldwide has #migraine. Make protecting us from #disability a priority.
.@NBCJoshua Illegal, not medical, #opioid use fuels ODs, which have risen exponentially since at least 1979, predating more liberal prescribing patterns. Addiction & use aren't rising: people are taking increasingly lethal drugs & combinations of drugs. /thread
.@TheWeekMSNBC "Overprescription" isn't "fueling the OD crisis." @AmericanCancer says #addiction in medical use is "very rare." #CDC Guideline is based on an average 96% unremarkable use; 4% includes nonaddictive misuse & long use. Large studies put addiction rate under 1%. 2/
Canada's Guideline: 96.7% unremarkable use; 3.3% includes nonaddictive misuse & abuse, in keeping w/ #CDC's Guideline. Brat et al. found a 99.4% rate of unremarkable use in more than 1 million post-op opioid scripts. 0.6% included people who refilled their scripts (BMJ 2018). 3/
Risk of OD to prescribed #opioids is 0.13% (Kaiser, Jnl of Pain 2019), while risk of death by OD increases more than 300% with dose variability of ≥30% (JAMA 2019).
VHA study: discontinuation increases the risk of death by #OD or #suicide up to 6.8 times (BMJ 2020). / thread
0.13% = risk of OD to prescribed #opioids (Kaiser 2019). Dose reduction is "inconsistent" in lowering OD risk. Research found "no support for RSM [risk stratification & monitoring] as a means of decreasing overdose.”
New OFFICIAL Classification of Diseases: #Migraine is not chronic 2ndary pain ("a symptom of an underlying condition") but chronic primary pain ("disability or emotional distress" not "accounted for" by a condition of “known etiology or established pathophysiology") >thread
#Migraine & #cluster are now officially classified as chronic primary pain (disability & emotional distress not accounted for by an underlying condition), not chronic secondary pain "where pain may at least initially be conceived as a symptom secondary to an underlying disease."