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24 Nov, 4 tweets, 3 min read
“[W]idespread & variable dysfunction of the nervous system…comprises the aberrant brain state of a #migraine attack” (Charles 2017).

Daily/near-daily migraine is continuous migraine. Imaging shows our brains *always* look like brains during an "attack" (Brennan 2018). >thread
Recurrent #migraine & #pain aren't benign. “Long-lasting &/or repetitive pain over years leads to profound functional as well as structural changes in the brain networks" (Brennan).

Ineffective treatment is a leading risk of progression to continuous migraine. #MedicalTwitter
Brennan & Pietrobon's paper "A Systems Neuroscience Approach to #Migraine" (Neuron 2018) is @headsUPmigraine's favorite. I excerpted it for others like me who aren't fluent in #neurochemistry:

docs.google.com/document/u/2/d…
Charles's paper is a good place to begin if you're a #migraine patient hoping to better understand your brain:

Charles A. The pathophysiology of migraine: implications for clinical management. The Lancet Neurology. 2018 Feb 1;17(2):174-82. hartp.neurology.ucla.edu/assets/lancetn…

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More from @JillPiggott

Jill Piggott Profile picture
25 Nov
“#Migraine is a neurological disorder, not a terrible, disabling #headache," expert @daviddodick explains. #Pain is "just 1 clinical manifestation deriving from a sensory processing disturbance affecting the nervous system" (Morgan, Lancet 2020). /Thread thelancet.com/journals/laneu…
Billie lost her insurance when #migraine disabled her: “There are days I don't see anything except for shapes." Visual warnings are the most commonly recognized auras, but these symptoms are highly variable, both in different patients & on different days for the same patient. 2/ Image
Difficulty speaking or speaking clearly is another common #migraine symptom, either preceding or during an attack.

Poor St. Husband. He watched this clip & said, "Yup, that's you." I spent a lotta years in school to talk like this. 3/
Read 7 tweets
Jill Piggott Profile picture
25 Nov
A Yale study of 10 patients found 1 dose of #psilocybin can cut #migraine frequency in half for 2 weeks. Each patient did 1 session with placebo, 1 with the drug. People who felt most high got the least migraine relief. /thread newatlas.com/health-wellbei…
The Yale researchers who conducted the small, but 1st of its kind study suggest #migraine patients might benefit from microdoses or sub-hallucinogenic doses of #psilocybin. Understanding how psilocybin prevents migraine might open new pathways for drug development, as well.
I did 2 #migraine clinical trials. I'm glad someone else took this one for the team. I hated Methysergide (Sansert), now discontinued, which was synthesized from lysergic #acid. A 1965 study said Sansert users experienced a "confused feeling of unreality." Tell me about it.
Read 7 tweets
Jill Piggott Profile picture
23 Nov
It's hard to browse #library bookshelves from home. For other homebound readers, NYT best fiction 2009-19 as a thread for non-subscribers. (Your local library might let you read NYT etc on their website.)

Public libraries are my #SacredPlaces. #books nytimes.com/article/top-bo…
2019: DISAPPEARING EARTH Julia Phillips. THE TOPEKA SCHOOL Ben Lerner. EXHALATION Ted Chiang. LOST CHILDREN ARCHIVE Valeria Luiselli. NIGHT BOAT TO TANGIER Kevin Barry
2018: ASYMMETRY Lisa Halliday. THE GREAT BELIEVERS Rebecca Makkai. THE PERFECT NANNY Leila Slimani. Translated Sam Taylor. THERE THERE Tommy Orange. WASHINGTON BLACK Esi Edugyan.
Read 12 tweets
Jill Piggott Profile picture
22 Nov
Holiday shopping from home? Support #Maine #Wabanaki businesses. The Wabanaki are the Maliseet, Passamaquoddy, Penobscot, Mi'kmaq, and Abenki People of the Dawn. #mepolitics #indigenous <thread>

#Passamaquoddy handmade moccasins facebook.com/PassamaquoddyF…
Who doesn't love a little syrup in their stockings? #Passamaquoddy maple syrup from #Maine. passamaquoddymaple.com/?fbclid=IwAR1V…
Meherrin Outpost is owned & operated by a Mi'kmaq (#Maine) & #Mehrrin (NC) couple. They make jewelry & sell a wide range of products from sage & sweetgrass to hand drums and (aw!) baby moccasins. facebook.com/meherrin/
Read 10 tweets
Jill Piggott Profile picture
21 Nov
Even if they support the #DeathPenalty, most people think that only people who've killed should be killed.

🔴Prosecutors never claimed #DustinHiggs killed anyone, but #Barr has scheduled him to die 5 days before inauguration. Deeply moving video: /thread vimeo.com/194702182
#DustinHiggs was in his early 20s when he drove a shooter from a crime scene. Prosecutors said the shooter "acted alone," but they failed to get the #DeathPenalty. So they accused Higgs of being the mastermind.

The shooter got life w/ no parole. Higgs is to die on 1/15/21.
Jurors did NOT hear mitigating factors that might've led them to choose death in prison by no parole over execution. They didn't know he was 10 when he was his mother's f/t caretaker as she died of breast cancer. Nor did they know he has learning & developmental disabilities.
Read 4 tweets
Jill Piggott Profile picture
21 Nov
✔️Trump & #Barr are on a #KillingSpree. The official cause of death for executions is homicide.

If there are no more stays, they'll have killed 13 in 7 months compared to 3 in the 222 months since McVeigh's execution in June 2001. | thread
Dept of Justice website: "There is no proof that the #DeathPenalty deters criminals."

Death in prison by no parole (not execution) saves +/-$1 million per case. The capital punishment error rate is 1 in 10: 1 exoneration for every 9 executions. nij.ojp.gov/topics/article…
Chart source: Wikipedia, List of people executed by the US federal government

#Execution schedule 2020-21 & #DeathPenalty information: deathpenaltyinfo.org/executions/upc…
Read 6 tweets

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