Thread by @JillPiggott

A Yale study of 10 patients found 1 dose of #psilocybin can cut #migraine frequency in half for 2 weeks. Each patient did 1 session with placebo, 1 with the drug. People who felt most high got the least migraine relief. /thread newatlas.com/health-wellbei…

The Yale researchers who conducted the small, but 1st of its kind study suggest #migraine patients might benefit from microdoses or sub-hallucinogenic doses of #psilocybin. Understanding how psilocybin prevents migraine might open new pathways for drug development, as well.

I did 2 #migraine clinical trials. I'm glad someone else took this one for the team. I hated Methysergide (Sansert), now discontinued, which was synthesized from lysergic #acid. A 1965 study said Sansert users experienced a "confused feeling of unreality." Tell me about it.

I knew there wasn't a black dog slightly behind me the whole time I was taking Sansert, so it was highly irritating to "feel like" he was there. I have 0 tolerance for feeling drugged. I've had daily migraine since 8 & never drink or take non-rx meds. My brain's fuzzy enough.

I used to tell my black dog story whenever I taught Hawthorne b/c instead of Satan, Salem might've fallen victim to bread fungus: rye fungus causes ergotism & ergotism can cause hallucinations. Ergots are used to synthesize #LSD & treat, yep, #migraine.

And if you want to get technical about it, here's a #podcast discussing a 1965 article about 6 patients who experimented with #LSD, Methysergide (the #migraine drug Sansert), and #Psilocybin before the US gov't shut down research using "psychedelic" drugs.

@headsUPmigraine