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Alessandro Gozzi Profile picture
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7 Dec, 3 tweets, 3 min read
Out today @NeuroCellPress our work where we detail the wiring diagram of the mouse🐭default mode network (DMN)

👏👏Huge congrats & many thanks to @DrJigsaww @harrisjuliea and @AllenInstitute for leading the work & for such fruitful collaboration
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cell.com/neuron/fulltex…
Reposting the original thread below with summary of main findings and explanation of how these results may affect/guide your research

@NeuroCellPress version contains streamlined writing and more retro-seq data so all original @biorxive results hold
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And of course very grateful to funding agencies who supported this work (@ERC_Research #Disconn @IITalk ) and people in the lab who contributed to this research @adliska @ColettaLudovico 👏

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More from @Gozzi_Ale

Alessandro Gozzi Profile picture
16 Oct
Can we ‘see’ #autism in the brain? And is there a specific brain signature for the condition?

This is what we found by comparing brain connectivity maps across 16 mouse autism models
➡️tinyurl.com/yxfu2gzn

➡️Majestically led 👏👏👏by @Valerio_Zerbi @NCMLabETH

Thread 1/n
Autism is diagnosed based on behavior - but is this condition associated with a specific brain signature of circuit dysfunction?
Despite decades of work, brain imaging has failed to identify such signature as we have evidence of under-connectivity... tinyurl.com/y5uxoe3s

2/n
.....over-connectivity....
linkinghub.elsevier.com/retrieve/pii/S…

3/n
Read 14 tweets
Alessandro Gozzi Profile picture
9 Oct
#Autism is often associated with an excess of synapses:
but how does this trait affect large-scale circuit function?

Here's what we found by modelling autism-related pruning deficits across-species🧠🐭
➡️tinyurl.com/y2yfj74o

By @MarcoPagani1985 @mvlombardo & al.

Thread 1/n
Postmortem investigations in idiopathic #Autism have consistently revealed an excess of excitatory synapses
tinyurl.com/y57cc4r5
tinyurl.com/y59mdffp
tinyurl.com/y3t64yfe

2/n
Seminal work form the #Sulzer_Lab @Columbia has shown that postmortem synaptic surplus in #Autism is associated with hyperactive mTOR signalling
➡️this is a molecular pathway often dysregulated in autism and a key point of convergence of many autism-risk genes

3/n
Read 19 tweets
Alessandro Gozzi Profile picture
7 Aug
Wondering whether axonal input *drives* fMRI-based functional connectivity? Us too!

Here is what we found using #chemogenetic deconstruction of rsfMRI in the mouse🐁🐭

➡️Cortical silencing results in paradoxical fMRI overconnectivity tinyurl.com/yy269j92

Thread below 1/n
Computational and empirical evidence suggest that structural and functional connectivity are robustly related

➡️ this recent review from @richardfbetzel @misicbata summarizes it all tinyurl.com/yyy5u3zm

2/n
⚠️A key prediction of structurally based models of fMRI coupling is that *inactivation* of a brain node would result in reduced rsfMRI connectivity with its targets⚠️

But is that really the case?

3/n
Read 19 tweets
Alessandro Gozzi Profile picture
15 May
**New preprint from the lab**

Regional, layer and cell-class specific connectivity of the mouse default mode network tinyurl.com/yddanw5w

Conceived & majestically led by @DrJigsaww @harrisjuliea @AllenInstitute

Thread covering DMN basics + implications of findings
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What is the Default Mode Network (DMN)?

👉Network identified in human PET/fMRI studies
👉Active and strongly synchronized during rest
👉Desynchronized by goal-oriented tasks
👉Encompasses associative cortices - Prefrontal, Cingulate, Retrosplenial, Parietal, Temporal

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Why study the DMN?

👉Most prominent large-scale network of human brain
👉Pivotal substrate for higher-order cognitive and social functions
👉Key point of vulnerability for autism, schizophrenia, Alzhemier's and other brain disorders (seminal feature review below)

3/n
Read 13 tweets

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