Thread by @fascinatorfun

PFIZER/MODERNA

📌really need 2 doses for maximal protection (time gap not evaluated here)

📌Vaccines looks generally good against #B117 & #B1429 (CA variant)

📌#P1 moderately poorer

📌#B1351 looks worrisome. #B1351 results looks akin to unrelated coronaviruses.

https://twitter.com/drericding/status/1371209487491735553

Unfortunately my efforts to return to the paper here keep failing.

BUT it is notable that another Harvard Pre print seems to bear the above results out esp re B1351 (SA variant)

10-12x fold drop

biorxiv.org/content/10.110…

I again remind everyone that antibody titers are only part of the immunity picture. Research, for instance by Prof Crotty’s team shows that B Cells (that can be prompted to produce antibodies INCREASE over time).

Then there’s T cells.

New AZ study interesting here

https://twitter.com/drneeltje/status/1370362200771104776

We know that people infected with SARS were showing effective T Cell responses 17 years later.

We may find the different vaccines work in different ways to provide protective immunity, for instance this study.

The above AZ study, albeit in hamsters is of interest.

“No infectious virus in lungs, no lung pathology, all whereas controls animals had a lot of virus in their lungs.

We obtained this result with very low virus neutralizing antibody titers in hamsters against B.1.351, undetectable in one animal. It’s not only about antibodies.”