1/n Usually we invite friends/colleagues to our SEDER, but no guests last & this year. Inspired by FB comment by @gregggonsalves I thought it’d be fun to share our dishes with #MedTwitter friends as if we’re together - see following thread #PCCMEats#HappyPassover2021
2/n Every item on the Seder Plate has a symbolic meaning in the ceremonial retelling of the Exodus story - except the Orange, a recent addition dedicated to #inclusion of those marginalized in traditional religions (women, LGBTQ) #NKsSederTweetorial#PCCMEats#HappyPassover2021
3/n The bitter & spicy taste of horseradish, fresh taste of greens & Sweet & earthy look of Harosset all symbolize aspects of the story - but biggest mystery is how well they fit together in a Matzah sandwich - or is it not? #NKsSederTweetorial#PCCMEats#HappyPassover2021
4/n We always ate hard boiled eggs in my family on the Seder, I don’t know why, some suggest they symbolize renewal or spring, but they go perfectly well with salted water and picked lemons #NKsSederTweetorial#PCCMEats#HappyPassover2021
5/n Gefilte Fish - much of Yiddish food originates in poverty, you don’t have enough fish to feed your family, you grind bones & unedible parts with egg & matzah flour, stuff the fish. I like them sweet as my mother used to make them, but order both sweet & salty from @ZabarsIsNY
6/n For Jews of Eastern European origin, even if born on the shores of Eastern Mediterranean like me, holidays remind us of our roots, schmaltz Herring, Chopped liver - I add pine nuts for taste & aesthetics & mediterranean feel #NKsSederTweetorial#PCCMEats#HappyPassover2021
8/n Chicken Soup with knedalech is one of my earliest memories & as a child I could not understand why we had to wait for holidays to have it - with the years I became a real expert in making them & secret is - it’s easy #NKsSederTweetorial#PCCMEats#HappyPassover2021
10/n Same goes for the Dessert, by the time the Seder has ended,songs,readings, so much food - who can eat? but then who can say no to Wine Poached Pears served in Chocolate Syrup? I can, but I do love making them #NKsSederTweetorial#PCCMEats#HappyPassover2021
• • •
Missing some Tweet in this thread? You can try to
force a refresh
2/n As expected, type-1 IFN signature dominates all cell types (with a uniquely IFN-activated CD8 T cell cluster). The signature correlates strongly with initial viral load and in repeated samples with time #COVID19#Covid19CellAtlasmedrxiv.org/content/10.110…
3/n A skewed immunopralysis like anti-inflammatory signature is found in monocytes of #COVID19 progressive patients, connectome analysis suggested disrupted connectivity between LAG3 and MHC signalling medrxiv.org/content/10.110…
2/n Among epithelial cells, we identified cells DISTINCT from ANY epithelial cells previously described in human lungs. These aberrant basaloid cells are at the edge of myofibroblast foci & express fibrotic molecules & regulators #IPFCellAtlas#CureIPFadvances.sciencemag.org/content/6/28/e…
3/n Among enodthelial cells we discovered a previously undescribed population of COL15A1+ CD31+ cells. They are usually restricted to the airway but in IPF are found in the lung parenchyma - what are they doing there? #IPFCellAtlas#scRNAseq#CureIPFadvances.sciencemag.org/content/6/28/e…
1/n Dr. Mark Siegel is a superb critical care physician, ethicist & legendary Internal Medicine Residency Program Director whose weekly notes I read eagerly. This week’s note is titled “what I’d say to new interns” #MarksWisdom#TipsForNewDocs#MedEd facebook.com/1444114056/pos…
2/n Siegel starts saying #COVID19 took away joys of orientation: pizza, hot dogs, cold beer, gelato, unscripted conversations & new friendships. But don’t worry, show up, work hard, don't worry, you'll do great & then follows with 14 SPECIFIC TIPS: #MarksWisdom#TipsForNewDocs
3/n Tip #1: Take your own histories. Charts are rife with inaccurate, missing information. Key exposures, mounting symptoms, details patients held back- until you asked. To paraphrase Osler, patients will tell you the diagnosis, if you listen. #MarksWisdom#TipsForNewDocs#MedEd
1/n This is a thread about microRNA therapeutics in pulmonary fibrosis summarizing the MiRagen call today - we've been collaborating for >6 years now through an NIH-NHLBI funded CADET II grant to develop mir-29 as a therapy - the progress is amazing! #CureIPF#Mir29
3/n Rusty Montgomery @rmontonio of MiRagen: The Mir-29 mimic Remlarsen has hit fibrosis targets in a phase 1 trial of Keloid formation - a phase II trial is happening #AntiKeloid#CureScarring
Reopening thread to our patients 1/8 (relevant also friends, neighbors, family, peers, all) - many years ago, a veteran of many wars told me that the days of ceasefire were very dangerous. This was because precautions were lifted but risk was still there (see next) #COVID19
Reopening thread to our patients 2/8 - During ceasefires soldiers & civilians are often injured because they let down their guards, while local commanders are not aware of ceasefire or simply disregard it. Do not let your guards down - #COVID19 is not gone yet #KeepSafe
Reopening thread to our patients 3/8 - The decision to open up now is operational and involves risk. There is nothing magical about June 1 - #COVID19 does not read the calendar & is not involved in local politics. The Pandemic is not over yet. Maintain your precautions
1/n Our teams at @YalePCCSM are awestruck by the courage and esprit de corps exhibited by so many of our @YaleMed colleagues that have joined forces with us to help care for the increasing numbers of critically ill #COVID19 patients in our units medicine.yale.edu/intmed/news-ar…
2/n We feel that the commitment and dedication exhibited without hesitation by so many of our colleagues who do not regularly care for medically critically ill patients need to be highlighted medicine.yale.edu/intmed/news-ar…
3/n Leaving your comfort zone is no easy task in normal times. But to be able to do it in the face of stress, uncertainty and even potential personal risk is simply nothing short of heroic.#COVID19#Solidarity#Heroes