Mia Malan Profile picture
31 Mar, 12 tweets, 5 min read
[Thread] 1. SA’s commercial #CovidVaccine roll-out will start in April, the government says. Which jabs will we use? For now, J&J (the same jabs used in the Sisonke implementation study) and Pfizer. We will also consider Moderna, but no deals yet.
2. Why are we using J&J + Pfizer? SA trials showed J&J works well against the new variant, #501YV2. Pfizer hasn’t been tested in SA, but lab tests suggest it has reduced efficacy @ 501Y.V2. But because the efficacy is high (95%), even the reduced efficacy will provide protection.
3. Have the jabs been approved for commercial use in SA? Pfizer received emergency use authorisation (called Section 21 approval in SA) in March. J&J has not yet been approved (only for research), but on Monday @SAHPRA1 said an announcement will be made “within the next days”.
4. How many J&J + Pfizer jabs have we bought? 11 million J&J + 20 million more are almost in the bag (they’ll mostly come from Aspen’s plant in Gqeberha). We’ve also procured 20 million Pfizer jabs. Doses were all directly bought from J&J/Aspen or Pfizer. bit.ly/3rCZngz
5. How many people will the J&J + Pfizer jabs cover? Because J&J requires only one dose, the 31 million doses will cover 31 million people. Because Pfizer requires two doses, the 20 million doses will cover 10 million people. So in total we’ve got doses for 41 million people.
6. When will the jabs arrive? We don’t have exact dates. But #CyrilRampahosa said we’ll get some of the J&J jabs in April (likely 2.8 million). #ZweliMkhize said in parliament he expects 600 000 Pfizer jabs (100 000 from #COVAX) by the end of March. Today’s the last day of March.
7. Who will get Pfizer jabs + who will get J&J shots? J&J will be used in rural areas a lot + for older people who'll find it hard to return for 2nd shots. Pfizer will be used in urban areas because it’s harder to store and city facilities are better equipped for complex storage.
8. How does storage differ? J&J can be stored in a refrigerator (2-8 degrees Celsius) for 3 months. Pfizer only lasts for 5 days in a refrigerator + requires a freezer (-20 degrees Celsius) to last for 14 days. For 6 months ultra-cold freezers (-70 degrees Celsius) are required.
9. When will your turn to get a jab arrive? If you’re a health worker: Feb-April (the Sisonke study had covered 251 707 workers by the end of Mon). If you fall in phase 2 (see slide): May-Oct (older people + those with comorbidities will come first). Phase 3: Nov-Jan/Feb 2022
10. #ZweliMkhize told the portfolio health committee in parliament on Tue “the entire adult population” will be vaccinated within a year (Feb - Feb). That’s roughly 40 million people. What’s the plan? Mkhize says he wants to vaccinate 200 000 people/day at more than 2000 sites.
11. How will the private sector help? Discovery says it can vaccinate up to 50 000 people a day from 1 May for 550 000 high-risk members. All medical schemes will have to pay for their members’ vaccinations.
12. How will you know where to go for your jab? You’ll have to register on the gov's EVDS system. Phase 2 candidates can start to register in April. The system will allocate a site closest to your work/home. Sites = hospitals, pharmacies, GPs, shops, conference centres, gyms etc.

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More from @miamalan

30 Mar
[Thread] 1.#CyrilRamaphosa: In SA we are not yet ready to return to normal life because of #COVID19. For the 2nd year we will have to limited our interactions during the Easter period. Over the last year we have recorded more than 1.5 million cases.
bit.ly/3fognEZ
2. #CyrilRamaphosa: For the past 2 weeks, our cases stayed stable and hospitalisations and deaths have declined. This is because South Africans have largely abided by the restrictions put in place.
3. #CyrilRamaphosa: Phase 1 of our vaccination programme for health workers will be completed within 3 months (it started on Feb 17).
Read 5 tweets
13 Mar
[Thread] 1. How are we doing with our J&J #Covid Sisonke study vaccinations in provinces? Most vaccinations have happened in Gauteng, KZN and Western Cape. Gender breakdown: 74% of jabs have been given to women #HealthWorkers. Source: @LindaGailBekker @DTHF_SA webinar, 13 March
2. Have we seen side effects/adverse events in SA's Sisonke #CovidVaccine study? 2.1% of "vaccinees" have reported minor adverse events, e.g. swelling/redness where they've been injected or mild headaches/body pain. Of those, about 96% have recovered or are busy getting better.
3. What side effects should you expect when injected with the Johnson & Johnson #CovidVaccine? Pain/swelling (at the site of injection), chills, tiredness, headaches. Most of these symptoms disappear within two days.
Read 4 tweets
12 Mar
[Thread] 1. To which #African countries have the new #COVID virus variants 1st identified in SA (501Y.V2/#B1351) + the UK (#B117) spread? To 21 countries so far — 8 have both variants. @bhekisisa_MG has created this map in collaboration with @mediahackza and Africa Data Hub.
2. The #501YV2 variant first identified in SA has spread to almost all Southern African countries. But the #B117 variant first identified in the UK, has now also been detected in South Africa — and so has a new variant first identified in Uganda. bit.ly/3bFqN0x
3. What are the implications of variants spreading? #B117 and #501YV2 spread faster than the original form of #SARSCoV2 (the virus the causes #COVID) because they’re more transmissible. That means more hospitalisations + deaths — because there are so many more #COVID cases.
Read 9 tweets
2 Mar
[Thread] 1. How long will it take for the J&J #CovidVaccine to be approved for full registration so we can use it for wider roll-out (outside a study setting) and is there a way around it? bit.ly/3r8Wfd2
2. Full registration by @SAHPRA1 for a branded medicine can take up to two years. But for #COVIDVaccines this process has been sped up - all jabs move right to the front of the queue. bit.ly/3r8Wfd2
3. J&J has applied for full registration via a rolling review (a review process where they submitted data throughout the efficacy trial they did, instead of submitting all info at the end of the trial, so it saves time and Sahpra doesn’t have to review all the data at once).
Read 10 tweets
28 Feb
Breaking: #Ramaphosa says SA moves from Alert Level 3 to Alert Level 1 from later this evening once the regulations have been gazetted. Gatherings will be permitted subject so limitations on size.
#Ramaphosa: Religious, social, political and cultural gatherings are allowed. The maximum nr of people at any gathering = 100 for indoor gatherings and 250 for outdoor gatherings.
#Ramaphosa: Nightclubs will remain closed. The sale of alcohol = permitted. But no alcohol can be sold during curfew hours. Masks are still mandatory. Failure to wear a mask remains a criminal offense.
Read 4 tweets
28 Feb
#Ramaphosa: A year after #COVID reached our shores, there are several safe and effective #COVIDVaccines. SA's scientists have led the way internationally with identifying variants.
#Ramaphosa: In the ten days since we launched our #COVID vaccination study/programme more than 60 000 #HealthWorkers have been vaccinated. A news batch of 80 000 J&J jabs arrived in SA yesterday.
#Ramaphosa: The number of #COVID vaccination sites will be expanded this week (for the second batch of 80 000 J&J vaccines) — from 17 to 49. Of the 49 sites, 32 will be at public health facilities and 17 at private health facilities.
Read 5 tweets

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